基于多模态大模型的儿童肺炎辅助诊断系统,提升基层医疗效率。
A Medical Multimodal Large Language Model for Pediatric Pneumonia
- 构建统一框架处理文本与影像数据,支持多种临床任务
- 在16.4万例真实病例上训练,覆盖胸片与CT等多种数据
- 通过专家验证的642样本基准测试,表现优于传统方法
儿童肺炎是全球五岁以下儿童死亡的主要原因,给家庭带来沉重负担。当前诊断与治疗面临三大挑战:症状与其他呼吸道疾病相似,难以快速准确鉴别;基层医院医疗资源与经验医生不足;个性化诊断报告与治疗建议生成耗时费力。为此,我们提出针对儿童肺炎的医学多模态大语言模型P2Med-MLLM,可在统一框架下完成自由文本放射科报告与病历生成等多样化临床任务。P2Med-MLLM可处理纯文本及图文数据,基于包含163,999例门诊与8,684例住院病例的真实临床数据集(P2Med-MD)进行训练,涵盖二维胸片、三维胸部CT图像、对应放射报告及门急诊记录。采用三阶段训练策略,使模型掌握医学知识并能遵循指令完成各类临床任务。为严格评估性能,我们构建了由儿科呼吸专科医生精心验证的P2Med-MBench基准,包含642个样本,覆盖六类临床决策支持任务及均衡的疾病分布。自动化评分结果显示P2Med-MLLM表现优异。该工作对辅助基层医生实现快速诊断与治疗规划具有重要意义,有助于降低重症死亡率并优化医疗资源配置。
原文摘要 · Abstract (English)
Pediatric pneumonia is the leading cause of death among children under five years worldwide, imposing a substantial burden on affected families. Currently, there are three significant hurdles in diagnosing and treating pediatric pneumonia. Firstly, pediatric pneumonia shares similar symptoms with other respiratory diseases, making rapid and accurate differential diagnosis challenging. Secondly, primary hospitals often lack sufficient medical resources and experienced doctors. Lastly, providing personalized diagnostic reports and treatment recommendations is labor-intensive and time-consuming. To tackle these challenges, we proposed a Medical Multimodal Large Language Model for Pediatric Pneumonia (P2Med-MLLM). It was capable of handling diverse clinical tasks, such as generating free-text radiology reports and medical records within a unified framework. Specifically, P2Med-MLLM can process both pure text and image-text data, trained on an extensive and large-scale dataset (P2Med-MD), including real clinical information from 163,999 outpatient and 8,684 inpatient cases. This dataset comprised 2D chest X-ray images, 3D chest CT images, corresponding radiology reports, and outpatient and inpatient records. We designed a three-stage training strategy to enable P2Med-MLLM to comprehend medical knowledge and follow instructions for various clinical tasks. To rigorously evaluate P2Med-MLLM's performance, we developed P2Med-MBench, a benchmark consisting of 642 meticulously verified samples by pediatric pulmonology specialists, covering six clinical decision-support tasks and a balanced variety of diseases. The automated scoring results demonstrated the superiority of P2Med-MLLM. This work plays a crucial role in assisting primary care doctors with prompt disease diagnosis and treatment planning, reducing severe symptom mortality rates, and optimizing the allocation of medical resources.
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