提出新型探头选择方法,提升脑部超声消融术前规划精度与效率
Development of Advanced FEM Simulation Technology for Pre-Operative Surgical Planning
- 基于有限元仿真构建多类型肿瘤热损伤数据库,支持术前精准预测
- 通过优化探头方向与位置,实现热损伤范围最小化、治疗时间最短化
- 适用于复杂脑部肿瘤消融,助力医生制定高效手术方案
体内针式治疗超声(NBTU)为恶性脑瘤(包括原发性和转移性)提供了微创热消融新途径。该技术利用高频交变电场驱动压电换能器,产生声波导致局部加热并杀灭肿瘤细胞,可在较低声功率下精准作用于靶区,保护周围正常组织。本文在前期工作基础上,构建了用于术前规划的仿真数据库,模拟不同组织环境下多种肿瘤类型和尺寸的消融效果,并发展扩展的仿真模型以评估跨组织条件下的热损伤。通过仿真生成涵盖四种方向探头的CEM43等效剂量图、温度变化、热剂量区域及最大消融距离等关键参数数据库。该数据库可为未来研究提供支持,辅助复杂路径规划与参数优化。此外,提出一种新型探头选择方法,通过避免不必要的热扩散并优化探头角度,提升治疗效率、缩短消融时间,具有改善患者预后和简化手术流程的潜力。本研究为提高NBTU临床应用中的精确性与疗效提供了坚实框架。
原文摘要 · Abstract (English)
Intracorporeal needle-based therapeutic ultrasound (NBTU) offers a minimally invasive approach for the thermal ablation of malignant brain tumors, including both primary and metastatic cancers. NBTU utilizes a high-frequency alternating electric field to excite a piezoelectric transducer, generating acoustic waves that cause localized heating and tumor cell ablation, and it provides a more precise ablation by delivering lower acoustic power doses directly to targeted tumors while sparing surrounding healthy tissue. Building on our previous work, this study introduces a database for optimizing pre-operative surgical planning by simulating ablation effects in varied tissue environments and develops an extended simulation model incorporating various tumor types and sizes to evaluate thermal damage under trans-tissue conditions. A comprehensive database is created from these simulations, detailing critical parameters such as CEM43 isodose maps, temperature changes, thermal dose areas, and maximum ablation distances for four directional probes. This database serves as a valuable resource for future studies, aiding in complex trajectory planning and parameter optimization for NBTU procedures. Moreover, a novel probe selection method is proposed to enhance pre-surgical planning, providing a strategic approach to selecting probes that maximize therapeutic efficiency and minimize ablation time. By avoiding unnecessary thermal propagation and optimizing probe angles, this method has the potential to improve patient outcomes and streamline surgical procedures. Overall, the findings of this study contribute significantly to the field of NBTU, offering a robust framework for enhancing treatment precision and efficacy in clinical settings.
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