攻击者通过设计缺失数据模式，操纵模型结果，甚至反转治疗效应方向。

Adversarial Missingness (AM) attacks aim to manipulate model fitting by carefully engineering a missing data problem to achieve a specific malicious objective. AM attacks are significantly different from prior data poisoning attacks in that no malicious data inserted and no data is maliciously perturbed. Current AM attacks are feasible only under the assumption that the modeler (victim) uses full-information maximum likelihood methods to handle missingness. This work aims to remedy this limitation of AM attacks; in the approach taken here, the adversary achieves their goal by solving a bi-level optimization problem to engineer the adversarial missingness mechanism, where the lower level problem incorporates a differentiable approximation of the targeted missingness remediation technique. As instantiations of this framework, AM attacks are provided for three popular techniques: (i) complete case analysis, (ii) mean imputation, and (iii) regression-based imputation for general empirical risk minimization (ERM) problems. Experiments on real-world data show that AM attacks are successful with modest levels of missingness (less than 20%). Furthermore, we show on the real-world Twins dataset that AM attacks can manipulate the estimated average treatment effect (ATE) as an instance of the general ERM problems: the adversary succeeds in not only reversing the sign, but also in substantially inflating the ATE values from a true value of -1.61% to a manipulated one as high as 10%. These experimental results hold when the ATE is calculated using multiple regression-based estimators with different architectures, even when the adversary is restricted to modifying only a subset of the training data.