通过动态图网络与任务掩码,提升自闭症脑功能连接分析精度。
MCDGLN: Masked Connection-based Dynamic Graph Learning Network for Autism Spectrum Disorder
- 用滑动窗口捕捉脑活动动态性,结合注意力机制筛选关键连接
- 在ABIDE I数据集上实现73.3%的自闭症分类准确率
- 适合神经科学与医学图像分析研究者参考
自闭症谱系障碍(ASD)是一种复杂的神经发育障碍。以往研究多关注静态脑功能连接,忽视了大脑动态特性及网络噪声问题。为此,我们提出掩码连接动态图学习网络(MCDGLN)。首先使用滑动时间窗分割BOLD信号以捕捉动态特征;随后引入加权边聚合(WEA)模块,通过通道式逐元素卷积融合动态功能连接,并提取任务相关连接;再通过分层图卷积网络(HGCN)提取拓扑特征,自注意力模块突出关键属性;核心在于利用定制化任务特定掩码优化静态连接,降低噪声并剔除无关链接;注意力连接编码器(ACE)进一步增强关键连接并压缩静态特征。最终特征用于分类。在1035名受试者的ABIDE I数据集上,该框架实现73.3%的自闭症与典型对照组分类准确率。WEA与ACE在连接精炼与分类性能提升中的关键作用,揭示了其在捕捉ASD特异性特征方面的价值。
原文摘要 · Abstract (English)
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by complex physiological processes. Previous research has predominantly focused on static cerebral interactions, often neglecting the brain's dynamic nature and the challenges posed by network noise. To address these gaps, we introduce the Masked Connection-based Dynamic Graph Learning Network (MCDGLN). Our approach first segments BOLD signals using sliding temporal windows to capture dynamic brain characteristics. We then employ a specialized weighted edge aggregation (WEA) module, which uses the cross convolution with channel-wise element-wise convolutional kernel, to integrate dynamic functional connectivity and to isolating task-relevant connections. This is followed by topological feature extraction via a hierarchical graph convolutional network (HGCN), with key attributes highlighted by a self-attention module. Crucially, we refine static functional connections using a customized task-specific mask, reducing noise and pruning irrelevant links. The attention-based connection encoder (ACE) then enhances critical connections and compresses static features. The combined features are subsequently used for classification. Applied to the Autism Brain Imaging Data Exchange I (ABIDE I) dataset, our framework achieves a 73.3\% classification accuracy between ASD and Typical Control (TC) groups among 1,035 subjects. The pivotal roles of WEA and ACE in refining connectivity and enhancing classification accuracy underscore their importance in capturing ASD-specific features, offering new insights into the disorder.
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