用患者病历轨迹预测一年后髋关节置换风险

Background: Hip replacement procedures improve patient lives by relieving pain and restoring mobility. Predicting hip replacement in advance could reduce pain by enabling timely interventions, prioritising individuals for surgery or rehabilitation, and utilising physiotherapy to potentially delay the need for joint replacement. This study predicts hip replacement a year in advance to enhance quality of life and health service efficiency. Methods: Adapting previous work using Temporal Graph Convolutional Neural Network (TG-CNN) models, we construct temporal graphs from primary care medical event codes, sourced from ResearchOne EHRs of 40-75-year-old patients, to predict hip replacement risk. We match hip replacement cases to controls by age, sex, and Index of Multiple Deprivation. The model, trained on 9,187 cases and 9,187 controls, predicts hip replacement one year in advance. We validate the model on two unseen datasets, recalibrating for class imbalance. Additionally, we conduct an ablation study and compare against four baseline models. Results: Our best model predicts hip replacement risk one year in advance with an AUROC of 0.724 (95% CI: 0.715-0.733) and an AUPRC of 0.185 (95% CI: 0.160-0.209), achieving a calibration slope of 1.107 (95% CI: 1.074-1.139) after recalibration. Conclusions: The TG-CNN model effectively predicts hip replacement risk by identifying patterns in patient trajectories, potentially improving understanding and management of hip-related conditions.