arXiv:2409.06687eess.IVcs.CV2024-09被引 7

用深度学习自动识别血涂片,提升白血病诊断速度与准确率。

A study on deep feature extraction to detect and classify Acute Lymphoblastic Leukemia (ALL)

  • 用预训练CNN模型提取血涂片特征,结合多种筛选方法优化关键信息。
  • ResNet101达到87%准确率,优于其他模型,可辅助临床诊断。
  • 适合医学影像分析、AI辅助诊疗研究者参考,尤其关注自动化诊断。

急性淋巴细胞白血病(ALL)是一种主要影响儿童和成人的血液恶性肿瘤。本研究探讨了卷积神经网络(CNN)在ALL检测与分类中的应用,以替代成本高且易出错的手动骨髓活检。研究采用InceptionV3、ResNet101、VGG19、DenseNet121、MobileNetV2等预训练模型从血涂片图像中提取特征,并通过ANOVA、递归特征消除(RFE)、随机森林、Lasso及主成分分析(PCA)筛选关键特征。随后使用朴素贝叶斯、随机森林、支持向量机(SVM)和K近邻(KNN)进行分类。结果显示,ResNet101表现最佳,准确率达87%,紧随其后的是DenseNet121和VGG19。研究指出,基于CNN的系统有望减少对医疗专家的依赖,提升诊断效率。为进一步提升性能,建议扩充多样化数据集,并探索Transformer等更复杂架构。

原文摘要 · Abstract (English)

Acute lymphoblastic leukaemia (ALL) is a blood malignancy that mainly affects adults and children. This study looks into the use of deep learning, specifically Convolutional Neural Networks (CNNs), for the detection and classification of ALL. Conventional techniques for ALL diagnosis, such bone marrow biopsy, are costly and prone to mistakes made by hand. By utilising automated technologies, the research seeks to improve diagnostic accuracy. The research uses a variety of pre-trained CNN models, such as InceptionV3, ResNet101, VGG19, DenseNet121, MobileNetV2, and DenseNet121, to extract characteristics from pictures of blood smears. ANOVA, Recursive Feature Elimination (RFE), Random Forest, Lasso, and Principal Component Analysis (PCA) are a few of the selection approaches used to find the most relevant features after feature extraction. Following that, machine learning methods like Naïve Bayes, Random Forest, Support Vector Machine (SVM), and K-Nearest Neighbours (KNN) are used to classify these features. With an 87% accuracy rate, the ResNet101 model produced the best results, closely followed by DenseNet121 and VGG19. According to the study, CNN-based models have the potential to decrease the need for medical specialists by increasing the speed and accuracy of ALL diagnosis. To improve model performance, the study also recommends expanding and diversifying datasets and investigating more sophisticated designs such as transformers. This study highlights how well automated deep learning systems do medical diagnosis.

医学影像深度学习白血病诊断CNN

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