OrthoDoc用12万张CT影像提升骨科病诊断准确率,防幻觉更可靠。
OrthoDoc: Multimodal Large Language Model for Assisting Diagnosis in Computed Tomography
- 基于12万张CT图像与报告训练,融合检索增强生成机制
- 在骨折、关节炎、肿瘤等常见病上超越GPT-4等商用模型
- 可稳定处理罕见复杂病例,适合临床辅助诊断场景
多模态大语言模型(MLLM)在图像处理领域取得显著进展,其任务泛化与自由对话能力可显著助力医学诊断,帮助患者理解病情并增强医患信任。计算机断层扫描(CT)是一种非侵入性成像技术,广泛用于捕捉患者内部结构信息。然而,以往研究中,该类影像数据复杂的纹理特征使得算法难以准确解读,限制了通用大模型在诊断辅助中的表现。为此,我们提出OrthoDoc,一种专为CT诊断设计的MLLM。OrthoDoc在12万张CT图像及对应的诊断报告上进行训练,并引入检索增强生成(RAG)模块,有效缓解模型幻觉问题。该模块依托大量医学文献、教科书和解释性数据,使模型不仅能处理复杂CT图像,还能存储、理解并推理医学知识与语言。在大量实验中,OrthoDoc优于以GPT-4为首的商用模型,在骨折、关节炎、肿瘤等常见骨科疾病的诊断上表现更优。此外,对于罕见和复杂病例,OrthoDoc展现出强泛化能力和稳定性。
原文摘要 · Abstract (English)
Multimodal large language models (MLLMs) have achieved significant success in the general field of image processing. Their emerging task generalization and freeform conversational capabilities can greatly facilitate medical diagnostic assistance, helping patients better understand their conditions and enhancing doctor-patient trust. Computed Tomography (CT) is a non-invasive imaging technique used to capture the internal mechanisms of a patient's condition and is widely utilized. However, in past research, the complex textural features of this imaging data have made accurate interpretation by algorithms challenging, impeding the performance of general LLMs in diagnostic assistance. To address this, we developed OrthoDoc, a MLLM designed for CT diagnostics. OrthoDoc is trained on 120,000 CT images and diagnostic reports and includes a Retrieval-Augmented Generation (RAG) module capable of effectively mitigating model hallucinations. This module is informed by extensive medical literature, textbooks, and explanatory data. Thus, OrthoDoc not only processes complex CT images but also stores, understands, and reasons over medical knowledge and language. In extensive experiments, OrthoDoc outperforms commercial models led by GPT-4, demonstrating superior diagnostic capabilities and accuracy. Specifically, OrthoDoc significantly surpasses existing models in the diagnosis of common orthopedic conditions such as fractures, arthritis, and tumors. Additionally, OrthoDoc exhibits robust generalization and stability when handling rare and complex cases.
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