arXiv:2409.11377cs.LG2024-09被引 4

用大规模fMRI数据评估脑功能连接建模,给出深度学习应用的实证指南。

Machine Learning on Dynamic Functional Connectivity: Promise, Pitfalls, and Interpretations

  • 基于3.5万份fMRI数据,系统评估主流模型在认知任务识别中的表现
  • 发现当前模型在疾病诊断上性能不稳定,且泛化能力受限于数据分布
  • 提出结合神经科学知识选择模型架构的实用原则,适合脑影像研究者参考

海量功能性磁共振成像(fMRI)数据为利用数据驱动方法理解脑功能波动与人类认知/行为的关系提供了新机遇。为此,机器学习领域已投入大量努力,试图从血氧水平依赖(BOLD)信号的动态体积图像中预测认知状态。然而,由于大脑功能的复杂性,现有最先进(SOTA)方法在学习性能和发现结果上常不一致。本文基于大规模公开神经影像数据(来自6个数据库,共34,887个样本),通过全面评估与统计分析,在不同设置下回答三个核心问题:(1)当前在认知任务识别和疾病诊断中,fMRI的SOTA表现如何?(2)现有深度模型存在哪些局限性?(3)如何为新的神经影像应用选择合适的机器学习主干网络?研究旨在建立一个基于实证、结合神经科学知识的深度模型设计指南。

原文摘要 · Abstract (English)

An unprecedented amount of existing functional Magnetic Resonance Imaging (fMRI) data provides a new opportunity to understand the relationship between functional fluctuation and human cognition/behavior using a data-driven approach. To that end, tremendous efforts have been made in machine learning to predict cognitive states from evolving volumetric images of blood-oxygen-level-dependent (BOLD) signals. Due to the complex nature of brain function, however, the evaluation on learning performance and discoveries are not often consistent across current state-of-the-arts (SOTA). By capitalizing on large-scale existing neuroimaging data (34,887 data samples from six public databases), we seek to establish a well-founded empirical guideline for designing deep models for functional neuroimages by linking the methodology underpinning with knowledge from the neuroscience domain. Specifically, we put the spotlight on (1) What is the current SOTA performance in cognitive task recognition and disease diagnosis using fMRI? (2) What are the limitations of current deep models? and (3) What is the general guideline for selecting the suitable machine learning backbone for new neuroimaging applications? We have conducted a comprehensive evaluation and statistical analysis, in various settings, to answer the above outstanding questions.

fMRI机器学习脑功能连接神经科学

Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。