发现多种肠道菌群可作为胃癌风险预测标志物。
Multivariate Analysis of Gut Microbiota Composition and Prevalence of Gastric Cancer
- 基于16S rRNA测序分析96名患者菌群数据，识别关联菌属。
- 揭示多个显著差异的细菌类群与胃癌风险相关。
- 为胃癌早期预警提供新思路，适合临床研究者参考。
全球胃癌病例激增促使人们探究肠道微生物组作为疾病预测标志物的潜力。肠道微生物多样性变化被认为与胃癌风险升高有关。本研究聚焦接受全胃切除或部分胃切除的患者，利用数据挖掘与统计学习方法，分析了96名参与者经16S-rRNA测序获得的基因数据，旨在识别与胃癌相关的特定菌属。研究揭示若干显著的细菌类群，可能作为评估胃癌风险的生物标志物。这些发现为胃癌的早期风险评估和预防措施提供了路径。这些肠道微生物影响胃癌进展的复杂机制仍需进一步研究。该研究显著推动了对肠-癌轴的理解及其在疾病预测与预防中的应用。
原文摘要 · Abstract (English)
The global surge in the cases of gastric cancer has prompted an investigation into the potential of gut microbiota as a predictive marker for the disease. The alterations in gut diversity are suspected to be associated with an elevated risk of gastric cancer. This paper delves into finding the correlation between gut microbiota and gastric cancer, focusing on patients who have undergone total and subtotal gastrectomy. Utilizing data mining and statistical learning methods, an analysis was conducted on 16S-RNA sequenced genes obtained from 96 participants with the aim of identifying specific genera of gut microbiota associated with gastric cancer. The study reveals several prominent bacterial genera that could potentially serve as biomarkers assessing the risk of gastric cancer. These findings offer a pathway for early risk assessment and precautionary measures in the diagnosis of gastric cancer. The intricate mechanisms through which these gut microbiotas influence gastric cancer progression warrant further investigation. This research significantly aims to contribute to the growing understanding of the gut-cancer axis and its implications in disease prediction and prevention.
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