用每秒3.3万帧的全息多普勒技术，无创测量视网膜动脉血流。
Retinal arterial blood flow measured by real-time Doppler holography at 33,000 frames per second
- 以每秒3.3万帧速度捕捉视网膜血流，实现高精度非侵入成像。
- 通过多普勒频谱展宽和前向散射模型，定量计算局部血流速度。
- 适合眼科疾病诊断与治疗监测，补充现有影像手段。
本研究提出一种基于实时全息多普勒技术的新方法，以33,000帧/秒的前所未有效率，定量估算视网膜动脉总血流。该技术利用高速数字全息，实现对视网膜的无创血管成像，提供关键的血流对比信息，有助于评估视网膜健康状态。所提分析方法包括对主要平面内视网膜动脉进行分割，并利用多普勒频谱展宽计算局部血流速度。分析过程结合前向散射模型，实现血流精确估计。结果表明，多普勒全息技术在诊断和监测视网膜血管疾病方面具有巨大潜力，可作为现有成像手段的有效补充。
原文摘要 · Abstract (English)
This study presents a novel quantitative estimation method for total retinal arterial blood flow utilizing real-time Doppler holography at an unprecedented frame rate of 33,000 frames per second. This technique, leveraging high-speed digital holography, enables non-invasive angiographic imaging of the retina, providing detailed blood flow contrasts essential for assessing retinal health. The proposed quantitative analysis method consists of segmenting primary in-plane retinal arteries and calculating local blood velocity using Doppler frequency broadening. The analysis integrates a forward scattering model to achieve blood flow estimation. Our findings highlight the potential of Doppler holography as a powerful tool for diagnosing and monitoring the treatment of retinal vascular conditions, complementary to existing imaging methods.
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