用多目标神经架构从多模态MRI中定位、分割和分级胶质瘤,提升早期诊断精度。
Targeted Neural Architectures in Multi-Objective Frameworks for Complete Glioma Characterization from Multimodal MRI
- 设计针对性网络结构,融合VGG19与图注意力机制增强多模态特征提取。
- 分割任务达96% IoU,分类准确率达98.53%,性能优异。
- 适合医学AI研究者和临床辅助诊断系统开发者参考。
脑肿瘤源于脑组织异常细胞增殖,若未及时诊断,可导致认知障碍、运动功能障碍及感觉丧失。随着肿瘤生长,颅内压升高,可能引发脑疝等致命并发症。早期诊断与治疗对控制病情进展至关重要。深度学习与人工智能正被广泛用于通过磁共振成像(MRI)辅助医生早期识别。本研究提出在多目标框架下构建靶向神经架构,实现从多模态MRI图像中对胶质瘤的定位、分割与分级。定位模块采用改进的LinkNet架构,引入受VGG19启发的编码器,并结合空间与图注意力机制,强化肿瘤区域特征提取与跨特征关联。分割任务使用以SeResNet101为编码器的LinkNet框架,达到96%的交并比(IoU)得分。分类任务则采用SeResNet152特征提取器与自适应提升分类器结合,实现98.53%的准确率。该多目标方法在完整胶质瘤表征上表现优异,有望推动医疗AI发展,实现更早诊断与更精准治疗。
原文摘要 · Abstract (English)
Brain tumors result from abnormal cell growth in brain tissue. If undiagnosed, they cause neurological deficits, including cognitive impairment, motor dysfunction, and sensory loss. As tumors grow, intracranial pressure increases, potentially leading to fatal complications such as brain herniation. Early diagnosis and treatment are crucial to controlling these effects and slowing tumor progression. Deep learning (DL) and artificial intelligence (AI) are increasingly used to assist doctors in early diagnosis through magnetic resonance imaging (MRI) scans. Our research proposes targeted neural architectures within multi-objective frameworks that can localize, segment, and classify the grade of these gliomas from multimodal MRI images to solve this critical issue. Our localization framework utilizes a targeted architecture that enhances the LinkNet framework with an encoder inspired by VGG19 for better multimodal feature extraction from the tumor along with spatial and graph attention mechanisms that sharpen feature focus and inter-feature relationships. For the segmentation objective, we deployed a specialized framework using the SeResNet101 CNN model as the encoder backbone integrated into the LinkNet architecture, achieving an IoU Score of 96%. The classification objective is addressed through a distinct framework implemented by combining the SeResNet152 feature extractor with Adaptive Boosting classifier, reaching an accuracy of 98.53%. Our multi-objective approach with targeted neural architectures demonstrated promising results for complete glioma characterization, with the potential to advance medical AI by enabling early diagnosis and providing more accurate treatment options for patients.
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