融合结构与功能磁共振信息，提升脑图谱配准精度

Although developed functional magnetic resonance imaging (fMRI) registration algorithms based on deep learning have achieved a certain degree of alignment of functional area, they underutilized fine structural information. In this paper, we propose a semi-supervised convolutional neural network (CNN) registration model that integrates both structural and functional MRI information. The model first learns to generate deformation fields by inputting structural MRI (T1w-MRI) into the CNN to capture fine structural information. Then, we construct a local functional connectivity pattern to describe the local fMRI information, and use the Bhattacharyya coefficient to measure the similarity between two fMRI images, which is used as a loss function to facilitate the alignment of functional areas. In the inter-subject registration experiment, our model achieved an average number of voxels exceeding the threshold of 4.24 is 2248 in the group-level t-test maps for the four functional brain networks (default mode network, visual network, central executive network, and sensorimotor network). Additionally, the atlas-based registration experiment results show that the average number of voxels exceeding this threshold is 3620. The results are the largest among all methods. Our model achieves an excellent registration performance in fMRI and improves the consistency of functional regions. The proposed model has the potential to optimize fMRI image processing and analysis, facilitating the development of fMRI applications.