arXiv:2410.00046eess.IVcs.CV2024-10

用多中心专家混合模型缓解医疗AI偏见,不需数据共享即可适配本地临床习惯。

Mixture of Multicenter Experts in Multimodal AI for Debiased Radiotherapy Target Delineation

  • 构建多中心专家混合框架,融合不同医院的临床策略
  • 少样本训练下在跨中心差异大或数据少时表现更优
  • 适合资源有限机构,支持本地化定制且无需数据交换

临床决策反映由区域患者群体和机构规范塑造的多样化策略。然而,现有医疗AI模型大多基于高流行数据模式训练,强化了偏见,未能涵盖临床经验的多样性。受最近混合专家(MoE)进展启发,我们提出一种多中心专家混合(MoME)框架,以解决医疗领域中的AI偏见问题,且无需跨机构数据共享。MoME整合来自不同临床策略的专业知识,提升模型在各医学中心间的泛化性与适应性。我们在前列腺癌放疗靶区勾画的多模态模型中验证该框架。通过每个中心少量影像与临床文本联合训练,模型在跨中心差异大或数据稀缺场景下超越基线。此外,MoME可在不交换跨机构数据的前提下实现模型对本地临床偏好的定制,特别适用于资源受限环境,推动更具普适性的医疗AI发展。

原文摘要 · Abstract (English)

Clinical decision-making reflects diverse strategies shaped by regional patient populations and institutional protocols. However, most existing medical artificial intelligence (AI) models are trained on highly prevalent data patterns, which reinforces biases and fails to capture the breadth of clinical expertise. Inspired by the recent advances in Mixture of Experts (MoE), we propose a Mixture of Multicenter Experts (MoME) framework to address AI bias in the medical domain without requiring data sharing across institutions. MoME integrates specialized expertise from diverse clinical strategies to enhance model generalizability and adaptability across medical centers. We validate this framework using a multimodal target volume delineation model for prostate cancer radiotherapy. With few-shot training that combines imaging and clinical notes from each center, the model outperformed baselines, particularly in settings with high inter-center variability or limited data availability. Furthermore, MoME enables model customization to local clinical preferences without cross-institutional data exchange, making it especially suitable for resource-constrained settings while promoting broadly generalizable medical AI.

医疗AI多中心学习去偏见放疗勾画

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