arXiv:2410.00665q-bio.NCcs.LG2024-10被引 3

用动态图神经网络捕捉神经元连接随行为变化的规律,提升可解释性。

Graph-Based Representation Learning of Neuronal Dynamics and Behavior

  • 融合概率图学习与时序注意力,建模神经连接的动态演化
  • 在三个不同数据集上实现最优分类与聚类性能
  • 适用于真实与合成生物系统,适合神经动力学研究者

理解神经网络如何响应外部刺激重组并产生行为,是神经科学与人工智能的核心挑战。现有方法难以在动态、不确定或高维场景下,以足够分辨率和可解释性捕捉神经连接的演变。我们提出时序注意力增强的变分图循环神经网络(TAVRNN),通过整合概率图学习与时序注意力机制,建模随时间变化的神经连接。TAVRNN 在单单元层面学习潜在动态,同时保持可解释的群体表征,识别与行为相关的关键连接模式。该模型在三种不同数据集上验证:(1) 自由活动大鼠的电生理数据,(2) 猴子体感皮层在抓取任务中的记录,(3) DishBrain平台中生物神经元与虚拟游戏环境的交互。TAVRNN优于现有动态嵌入技术,揭示了行为适应性与神经网络拓扑结构演化的新型关联。结果表明,TAVRNN是一种强大且通用的神经动力学建模方法,其架构与模态无关、可扩展,适用于多种神经记录平台与行为范式。

原文摘要 · Abstract (English)

Understanding how neuronal networks reorganize in response to external stimuli and give rise to behavior is a central challenge in neuroscience and artificial intelligence. However, existing methods often fail to capture the evolving structure of neural connectivity in ways that capture its relationship to behavior, especially in dynamic, uncertain, or high-dimensional settings with sufficient resolution or interpretability. We introduce the Temporal Attention-enhanced Variational Graph Recurrent Neural Network (TAVRNN), a novel framework that models time-varying neuronal connectivity by integrating probabilistic graph learning with temporal attention mechanisms. TAVRNN learns latent dynamics at the single-unit level while maintaining interpretable population-level representations, to identify key connectivity patterns linked to behavior. TAVRNN generalizes across diverse neural systems and modalities, demonstrating state-of-the-art classification and clustering performance. We validate TAVRNN on three diverse datasets: (1) electrophysiological data from a freely behaving rat, (2) primate somatosensory cortex recordings during a reaching task, and (3) biological neurons in the DishBrain platform interacting with a virtual game environment. Our method outperforms state-of-the-art dynamic embedding techniques, revealing previously unreported relationships between adaptive behavior and the evolving topological organization of neural networks. These findings demonstrate that TAVRNN offers a powerful and generalizable approach for modeling neural dynamics across experimental and synthetic biological systems. Its architecture is modality-agnostic and scalable, making it applicable across a wide range of neural recording platforms and behavioral paradigms.

神经动力学图神经网络动态建模

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