提出新方法处理可变长度脑电数据,提升癫痫病灶定位准确率
Stochastic Sparse Sampling: A Framework for Variable-Length Medical Time Series Classification
- 通过稀疏采样固定窗口生成局部预测,再融合为全局判断
- 在4个医疗中心数据上优于现有方法,跨中心泛化能力更强
- 可可视化局部预测,帮助医生理解关键脑区信号特征
尽管多数时间序列分类研究聚焦于定长序列,但医疗领域中可变长度时间序列分类(VTSC)仍至关重要,因患者间及事件间的序列长度存在差异。为此,我们提出随机稀疏采样(SSS)框架,专用于医疗时间序列的VTSC。SSS通过稀疏采样固定窗口计算局部预测,并聚合校准以形成全局预测。我们将该方法应用于癫痫发作起始区(SOZ)定位这一关键任务,需从可变长度脑电图(iEEG)序列中识别致痫脑区。在来自四个独立医学中心的癫痫颅内脑电多中心数据集上评估,SSS在多数中心的表现优于现有最先进方法,在所有未见的外部中心(OOD)也表现更优。此外,SSS能自然提供后验洞察:通过可视化信号中时间平均的局部预测,揭示与SOZ相关的局部信号特征。
原文摘要 · Abstract (English)
While the majority of time series classification research has focused on modeling fixed-length sequences, variable-length time series classification (VTSC) remains critical in healthcare, where sequence length may vary among patients and events. To address this challenge, we propose $\textbf{S}$tochastic $\textbf{S}$parse $\textbf{S}$ampling (SSS), a novel VTSC framework developed for medical time series. SSS manages variable-length sequences by sparsely sampling fixed windows to compute local predictions, which are then aggregated and calibrated to form a global prediction. We apply SSS to the task of seizure onset zone (SOZ) localization, a critical VTSC problem requiring identification of seizure-inducing brain regions from variable-length electrophysiological time series. We evaluate our method on the Epilepsy iEEG Multicenter Dataset, a heterogeneous collection of intracranial electroencephalography (iEEG) recordings obtained from four independent medical centers. SSS demonstrates superior performance compared to state-of-the-art (SOTA) baselines across most medical centers, and superior performance on all out-of-distribution (OOD) unseen medical centers. Additionally, SSS naturally provides post-hoc insights into local signal characteristics related to the SOZ, by visualizing temporally averaged local predictions throughout the signal.
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