arXiv:2410.08228eess.IVcs.CV2024-10被引 14

融合多脑图谱信息,提升神经疾病脑网络分类精度

Multi-Atlas Brain Network Classification through Consistency Distillation and Complementary Information Fusion

  • 用解耦Transformer提取跨图谱一致连接特征
  • 在4个疾病数据集上准确率优于现有方法
  • 适合神经影像分析与脑疾病辅助诊断研究者

在神经科学中,通过脑网络识别与神经系统疾病相关的独特模式至关重要。静息态功能磁共振成像(fMRI)通过关联不同脑区的血氧水平依赖(BOLD)信号来绘制脑网络,这些脑区定义为感兴趣区域(ROIs)。脑网络构建依赖于脑图谱对大脑进行分区,但目前缺乏统一的标准图谱,限制了对疾病异常的检测。虽有研究采用多图谱方法,但忽略了图谱间的一致性,且缺乏ROI级信息交互。为此,本文提出图谱整合蒸馏与融合网络(AIDFusion),通过解耦Transformer过滤图谱特异性信息,蒸馏出跨图谱可区分的连接特征,并引入个体与群体层面的一致性约束以增强跨图谱一致性。此外,AIDFusion设计跨图谱消息传递机制,融合各脑区互补信息。在四个不同疾病数据集上的实验表明,AIDFusion在分类性能和效率上均优于当前先进方法。案例研究显示,该模型提取的模式既具可解释性,又与已知神经科学发现一致。

原文摘要 · Abstract (English)

In the realm of neuroscience, identifying distinctive patterns associated with neurological disorders via brain networks is crucial. Resting-state functional magnetic resonance imaging (fMRI) serves as a primary tool for mapping these networks by correlating blood-oxygen-level-dependent (BOLD) signals across different brain regions, defined as regions of interest (ROIs). Constructing these brain networks involves using atlases to parcellate the brain into ROIs based on various hypotheses of brain division. However, there is no standard atlas for brain network classification, leading to limitations in detecting abnormalities in disorders. Some recent methods have proposed utilizing multiple atlases, but they neglect consistency across atlases and lack ROI-level information exchange. To tackle these limitations, we propose an Atlas-Integrated Distillation and Fusion network (AIDFusion) to improve brain network classification using fMRI data. AIDFusion addresses the challenge of utilizing multiple atlases by employing a disentangle Transformer to filter out inconsistent atlas-specific information and distill distinguishable connections across atlases. It also incorporates subject- and population-level consistency constraints to enhance cross-atlas consistency. Additionally, AIDFusion employs an inter-atlas message-passing mechanism to fuse complementary information across brain regions. Experimental results on four datasets of different diseases demonstrate the effectiveness and efficiency of AIDFusion compared to state-of-the-art methods. A case study illustrates AIDFusion extract patterns that are both interpretable and consistent with established neuroscience findings.

脑网络fMRI多图谱分类

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