用蒸馏扩散模型直接优化语音合成指标，速度更快、质量更高。

Diffusion models have demonstrated significant potential in speech synthesis tasks, including text-to-speech (TTS) and voice cloning. However, their iterative denoising processes are computationally intensive, and previous distillation attempts have shown consistent quality degradation. Moreover, existing TTS approaches are limited by non-differentiable components or iterative sampling that prevent true end-to-end optimization with perceptual metrics. We introduce DMOSpeech, a distilled diffusion-based TTS model that uniquely achieves both faster inference and superior performance compared to its teacher model. By enabling direct gradient pathways to all model components, we demonstrate the first successful end-to-end optimization of differentiable metrics in TTS, incorporating Connectionist Temporal Classification (CTC) loss and Speaker Verification (SV) loss. Our comprehensive experiments, validated through extensive human evaluation, show significant improvements in naturalness, intelligibility, and speaker similarity while reducing inference time by orders of magnitude. This work establishes a new framework for aligning speech synthesis with human auditory preferences through direct metric optimization. The audio samples are available at https://dmospeech.github.io/.