用机器学习从稳态数据快速估算冠脉搏动血流,精度高且不依赖网格划分。
Deep vectorised operators for pulsatile hemodynamics estimation in coronary arteries from a steady-state prior
- 基于神经场与消息传递/自注意力机制,构建可处理无限维函数空间的深度向量化算子。
- 在74例狭窄冠脉上,速度与压力估计误差仅0.368±0.079,接近真实仿真结果。
- 模型对网格重采样无关,适合临床实际中不同成像分辨率的数据输入。
心血管血流动力学场为冠状动脉疾病提供重要诊疗指标。计算流体力学(CFD)是此类量非侵入式仿真评估的金标准。本文提出一种基于机器学习的时间高效代理模型,用于从稳态先验信息中估算搏动血流动力学。我们引入深度向量化算子,一种可在无限维函数空间上实现离散化无关学习的建模框架。其底层神经架构为条件于血流边界条件的神经场。关键突破在于,将点对点作用放松为置换等变性,从而使得模型可由消息传递与自注意力层参数化。我们在74例来自冠状动脉计算机断层血管造影(CCTA)的狭窄冠脉数据集上进行评估,以患者特异性搏动CFD模拟作为真值。结果表明,模型对搏动速度与压力的估计准确率高(近似差异0.368±0.079),且对源域重采样无敏感性(ANOVA检验p<0.05),即具备离散化无关性。这证明深度向量化算子是冠脉血流动力学估计的强大工具,且具有广泛适用潜力。
原文摘要 · Abstract (English)
Cardiovascular hemodynamic fields provide valuable medical decision markers for coronary artery disease. Computational fluid dynamics (CFD) is the gold standard for accurate, non-invasive evaluation of these quantities in silico. In this work, we propose a time-efficient surrogate model, powered by machine learning, for the estimation of pulsatile hemodynamics based on steady-state priors. We introduce deep vectorised operators, a modelling framework for discretisation-independent learning on infinite-dimensional function spaces. The underlying neural architecture is a neural field conditioned on hemodynamic boundary conditions. Importantly, we show how relaxing the requirement of point-wise action to permutation-equivariance leads to a family of models that can be parametrised by message passing and self-attention layers. We evaluate our approach on a dataset of 74 stenotic coronary arteries extracted from coronary computed tomography angiography (CCTA) with patient-specific pulsatile CFD simulations as ground truth. We show that our model produces accurate estimates of the pulsatile velocity and pressure (approximation disparity 0.368 $\pm$ 0.079) while being agnostic ($p < 0.05$ in a one-way ANOVA test) to re-sampling of the source domain, i.e. discretisation-independent. This shows that deep vectorised operators are a powerful modelling tool for cardiovascular hemodynamics estimation in coronary arteries and beyond.
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