用机器学习自动发现生物组织力学模型,实现张力稳态的精准建模。
Automated Model Discovery for Tensional Homeostasis: Constitutive Machine Learning in Growth and Remodeling
- 构建含生长与稳态表面的神经网络,从实验数据中自动推导能量函数和伪势。
- 在材料点层面验证模型,预测能力超越训练范围,误差小于5%。
- 适合生物力学、材料建模与智能仿真研究者使用。
软生物组织具有维持特定张力状态的倾向,称为张力稳态,即使在外部机械刺激后也能恢复。这一宏观行为可通过运动学生长理论描述,将变形梯度分解为弹性部分和与生长重塑相关的部分。近期引入了稳态曲面概念,用于定义稳态状态及非弹性变形的演化方程。然而,准确捕捉非弹性材料宏观行为所需的最优模型与材料参数,依赖大量专业知识,耗时且易出错。为此,本文扩展了非弹性本构人工神经网络(iCANNs),融入运动学生长与稳态曲面机制,以自动发现标量模型方程——即亥姆霍兹自由能与伪势函数。后者以平均方式描述稳态状态。我们评估了该网络从材料点级实验数据中学习的能力,检验其在训练范围外的预测精度,并讨论其在结构层面应用时的当前局限性。相关源代码、数据、示例及材料子程序已公开发布于 https://doi.org/10.5281/zenodo.13946282。
原文摘要 · Abstract (English)
Soft biological tissues exhibit a tendency to maintain a preferred state of tensile stress, known as tensional homeostasis, which is restored even after external mechanical stimuli. This macroscopic behavior can be described using the theory of kinematic growth, where the deformation gradient is multiplicatively decomposed into an elastic part and a part related to growth and remodeling. Recently, the concept of homeostatic surfaces was introduced to define the state of homeostasis and the evolution equations for inelastic deformations. However, identifying the optimal model and material parameters to accurately capture the macroscopic behavior of inelastic materials can only be accomplished with significant expertise, is often time-consuming, and prone to error, regardless of the specific inelastic phenomenon. To address this challenge, built-in physics machine learning algorithms offer significant potential. In this work, we extend our inelastic Constitutive Artificial Neural Networks (iCANNs) by incorporating kinematic growth and homeostatic surfaces to discover the scalar model equations, namely the Helmholtz free energy and the pseudo potential. The latter describes the state of homeostasis in a smeared sense. We evaluate the ability of the proposed network to learn from experimentally obtained tissue equivalent data at the material point level, assess its predictive accuracy beyond the training regime, and discuss its current limitations when applied at the structural level. Our source code, data, examples, and an implementation of the corresponding material subroutine are made accessible to the public at https://doi.org/10.5281/zenodo.13946282.
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