用图像引导机器人精准定位脑磁刺激线圈,提升重复性与准确性。
An Image-Guided Robotic System for Transcranial Magnetic Stimulation: System Development and Experimental Evaluation
- 基于脑部精细影像建立标准化线圈定位参考系
- 位置误差减半,旋转精度提升近百倍
- 适合需要高重复性神经调控实验的研究者
经颅磁刺激(TMS)是一种非侵入性脑活动调控技术,广泛应用于神经科学和神经病学研究。相比人工操作,机器人可凭借更高精度和重复性改善TMS效果。然而,目前尚无基于精细脑部影像的机器人TMS标准协议,导致线圈角度设定随意,未充分考虑皮层真实边界。最新仿真研究表明,不同解剖细节对结果影响显著,因此皮层形态应成为确定最优线圈姿态的关键因素。本文提出一种图像引导的机器人TMS系统,重点解决两个问题:(1) 建立标准化规划方法与启发式规则,定义线圈姿态的参考基准(真实零点);(2) 克服人工放置依赖手眼协调、重复性差的问题。通过体模实验和初步人体试验验证系统性能。结果表明,机器人方法将位置误差降低50%,旋转精度最高提升两个数量级,多次试验的标准差下降一个数量级,显示出良好重复性。更高的执行精度有效转化为TMS应用优势,在磁场传感器中实现更高且更稳定的感应电压。
原文摘要 · Abstract (English)
Transcranial magnetic stimulation (TMS) is a noninvasive medical procedure that can modulate brain activity, and it is widely used in neuroscience and neurology research. Compared to manual operators, robots may improve the outcome of TMS due to their superior accuracy and repeatability. However, there has not been a widely accepted standard protocol for performing robotic TMS using fine-segmented brain images, resulting in arbitrary planned angles with respect to the true boundaries of the modulated cortex. Given that the recent study in TMS simulation suggests a noticeable difference in outcomes when using different anatomical details, cortical shape should play a more significant role in deciding the optimal TMS coil pose. In this work, we introduce an image-guided robotic system for TMS that focuses on (1) establishing standardized planning methods and heuristics to define a reference (true zero) for the coil poses and (2) solving the issue that the manual coil placement requires expert hand-eye coordination which often leading to low repeatability of the experiments. To validate the design of our robotic system, a phantom study and a preliminary human subject study were performed. Our results show that the robotic method can half the positional error and improve the rotational accuracy by up to two orders of magnitude. The accuracy is proven to be repeatable because the standard deviation of multiple trials is lowered by an order of magnitude. The improved actuation accuracy successfully translates to the TMS application, with a higher and more stable induced voltage in magnetic field sensors.
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