用生成扩散模型预测多通道脑电未来趋势，实现癫痫发作早期预警。

Multi-channel EEG signals are commonly used for the diagnosis and assessment of diseases such as epilepsy. Currently, various EEG diagnostic algorithms based on deep learning have been developed. However, most research efforts focus solely on diagnosing and classifying current signal data but do not consider the prediction of future trends for early warning. Additionally, since multi-channel EEG can be essentially regarded as the spatio-temporal signal data received by detectors at different locations in the brain, how to construct spatio-temporal information representations of EEG signals to facilitate future trend prediction for multi-channel EEG becomes an important problem. This study proposes a multi-signal prediction algorithm based on generative diffusion models (EEG-DIF), which transforms the multi-signal forecasting task into an image completion task, allowing for comprehensive representation and learning of the spatio-temporal correlations and future developmental patterns of multi-channel EEG signals. Here, we employ a publicly available epilepsy EEG dataset to construct and validate the EEG-DIF. The results demonstrate that our method can accurately predict future trends for multi-channel EEG signals simultaneously. Furthermore, the early warning accuracy for epilepsy seizures based on the generated EEG data reaches 0.89. In general, EEG-DIF provides a novel approach for characterizing multi-channel EEG signals and an innovative early warning algorithm for epilepsy seizures, aiding in optimizing and enhancing the clinical diagnosis process. The code is available at https://github.com/JZK00/EEG-DIF.