arXiv:2410.19667physics.med-phcs.LG2024-10被引 4

通过心电与心音数据,发现心脏在运动时存在记忆效应,可作为低成本筛查心脏病的指标。

Electromechanical Dynamics of the Heart: A Study of Cardiac Hysteresis During Physical Stress Test

  • 利用心电与心音同步信号分析心脏电-机械延迟关系
  • 运动中舒张期与心率几乎同步,收缩期延迟达28.3秒,QT段延迟10.5秒
  • 心率变化与心电-机械滞后环面积显著相关,可作功能评估新指标

心血管疾病需结合心脏电活动与机械功能多模态诊断。现有超声、核医学等技术成本高、难普及。本文基于EPHNOGRAM ECG-PCG数据集(23名健康男性,年龄25.4±1.9岁),分析运动状态下心电-心音时间间隔(RR、QT、收缩期、舒张期)及其相互作用,研究心脏电-机械迟滞现象。时间延迟分析显示,RR是主要驱动因素:舒张期与RR近乎同步,QT对RR变化平均延迟10.5秒,收缩期响应更慢,平均延迟28.3秒。研究发现舒张期RR滞后环较窄,收缩期则更宽。心率变化与滞后环面积平均相关系数达0.75,提示其等效圆直径或为潜在生物标志物。基于长短期记忆网络与卷积神经网络的深度学习模型,从RR预测其他间隔,验证了非线性关联。结果揭示心脏存在显著记忆效应,连接心电图与心音形态及节律的历史变化。

原文摘要 · Abstract (English)

Cardiovascular diseases are best diagnosed using multiple modalities that assess both the heart's electrical and mechanical functions. While effective, imaging techniques like echocardiography and nuclear imaging are costly and not widely accessible. More affordable technologies, such as simultaneous electrocardiography (ECG) and phonocardiography (PCG), may provide valuable insights into electromechanical coupling and could be useful for prescreening in low-resource settings. Using physical stress test data from the EPHNOGRAM ECG-PCG dataset, collected from 23 healthy male subjects (age: 25.4+/-1.9 yrs), we investigated electromechanical intervals (RR, QT, systolic, and diastolic) and their interactions during exercise, along with hysteresis between cardiac electrical activity and mechanical responses. Time delay analysis revealed distinct temporal relationships between QT, systolic, and diastolic intervals, with RR as the primary driver. The diastolic interval showed near-synchrony with RR, while QT responded to RR interval changes with an average delay of 10.5s, and the systolic interval responded more slowly, with an average delay of 28.3s. We examined QT-RR, systolic-RR, and diastolic-RR hysteresis, finding narrower loops for diastolic RR and wider loops for systolic RR. Significant correlations (average:0.75) were found between heart rate changes and hysteresis loop areas, suggesting the equivalent circular area diameter as a promising biomarker for cardiac function under exercise stress. Deep learning models, including Long Short-Term Memory and Convolutional Neural Networks, estimated the QT, systolic, and diastolic intervals from RR data, confirming the nonlinear relationship between RR and other intervals. Findings highlight a significant cardiac memory effect, linking ECG and PCG morphology and timing to heart rate history.

心脏病筛查心电心音滞后分析运动测试

Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。