用新模型分离基因型与环境因素,提升作物性状预测准确率
Disentangling Genotype and Environment Specific Latent Features for Improved Trait Prediction using a Compositional Autoencoder
- 设计分层自编码器,将高维表型数据分解为基因型和环境特异的潜在特征
- 在玉米数据集上,对吐丝天数和产量的预测性能提升5到10倍
- 适合精准育种与遗传研究,尤其关注环境互作效应的场景
本研究提出一种组合自编码器(CAE)框架,旨在解耦高维表型数据中基因型与环境因素的复杂交互,以提升植物育种与遗传项目中的性状预测能力。传统方法如主成分分析(PCA)、偏最小二乘回归(PLSR)及普通自编码器生成的紧凑表示无法区分基因型与环境特异性因素。我们假设将这两类特征解耦可增强预测模型。为此,构建了具有分层架构的组合自编码器(CAE),有效分离基因型特异与环境特异的潜在特征。在玉米多样性面板数据集上的实验表明,该方法显著提升了对吐丝天数和产量等关键性状的建模能力,相比传统方法(包括标准自编码器、PCA+回归、PLSR)预测性能提升5至10倍。通过解耦潜在特征,CAE为精准育种和遗传研究提供了有力工具,显著推动农业与生物科学的发展。
原文摘要 · Abstract (English)
This study introduces a compositional autoencoder (CAE) framework designed to disentangle the complex interplay between genotypic and environmental factors in high-dimensional phenotype data to improve trait prediction in plant breeding and genetics programs. Traditional predictive methods, which use compact representations of high-dimensional data through handcrafted features or latent features like PCA or more recently autoencoders, do not separate genotype-specific and environment-specific factors. We hypothesize that disentangling these features into genotype-specific and environment-specific components can enhance predictive models. To test this, we developed a compositional autoencoder (CAE) that decomposes high-dimensional data into distinct genotype-specific and environment-specific latent features. Our CAE framework employs a hierarchical architecture within an autoencoder to effectively separate these entangled latent features. Applied to a maize diversity panel dataset, the CAE demonstrates superior modeling of environmental influences and 5-10 times improved predictive performance for key traits like Days to Pollen and Yield, compared to the traditional methods, including standard autoencoders, PCA with regression, and Partial Least Squares Regression (PLSR). By disentangling latent features, the CAE provides powerful tool for precision breeding and genetic research. This work significantly enhances trait prediction models, advancing agricultural and biological sciences.
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