arXiv:2410.20204cs.LGcs.AI2024-10被引 4

梳理生成式AI在卫生经济研究中的应用,助力高效可靠决策

Generative AI in Health Economics and Outcomes Research: A Taxonomy of Key Definitions and Emerging Applications, an ISPOR Working Group Report

  • 构建生成式AI在卫生经济领域的术语分类体系
  • 提升文献综述与真实世界证据生成效率,支持模型自动化
  • 适合医药政策、临床研究者关注其应用边界与可靠性

本研究为卫生经济与结果研究(HEOR)领域提供生成式人工智能(AI)的术语分类体系,探讨其新兴应用并提出提升输出准确性的方法。通过定义基础概念,梳理当前在系统性文献回顾、卫生经济学建模、真实世界证据生成及注册资料撰写等场景的应用。介绍提示工程(零样本、少样本、思维链、角色提示)、检索增强生成、模型微调及领域专用模型等技术,以改善生成内容的准确性与可靠性。结果显示,生成式AI在提升工作效率与解决复杂问题方面潜力巨大,基础模型可自动化处理复杂任务,但仍面临科学可信度、偏见、可解释性及工作流整合等挑战。文章提出改进策略,强调需结合领域专业知识,并持续推动技术创新。结论认为,生成式AI有望重塑HEOR实践,但其全面应用需克服现有技术局限并发展专业能力。

原文摘要 · Abstract (English)

Objective: This article offers a taxonomy of generative artificial intelligence (AI) for health economics and outcomes research (HEOR), explores its emerging applications, and outlines methods to enhance the accuracy and reliability of AI-generated outputs. Methods: The review defines foundational generative AI concepts and highlights current HEOR applications, including systematic literature reviews, health economic modeling, real-world evidence generation, and dossier development. Approaches such as prompt engineering (zero-shot, few-shot, chain-of-thought, persona pattern prompting), retrieval-augmented generation, model fine-tuning, and the use of domain-specific models are introduced to improve AI accuracy and reliability. Results: Generative AI shows significant potential in HEOR, enhancing efficiency, productivity, and offering novel solutions to complex challenges. Foundation models are promising in automating complex tasks, though challenges remain in scientific reliability, bias, interpretability, and workflow integration. The article discusses strategies to improve the accuracy of these AI tools. Conclusion: Generative AI could transform HEOR by increasing efficiency and accuracy across various applications. However, its full potential can only be realized by building HEOR expertise and addressing the limitations of current AI technologies. As AI evolves, ongoing research and innovation will shape its future role in the field.

生成式AI卫生经济文献综述真实世界证据

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