用多模型图聚合法从脊柱CT中筛查肾上腺异常,提升漏诊率
Detection of adrenal anomalous findings in spinal CT images using multi model graph aggregation
- 构建三模型协同的图聚合框架,融合多切片信息定位异常
- 在真实临床数据上实现92.3%的异常检出率,误报率低于8%
- 适用于其他腹部器官筛查,可扩展至MRI等多模态影像
腰痛是基层医疗中最常见的主诉之一,一生中50%至80%的人口会经历。因此大量腰痛患者被转诊进行脊柱CT或MRI检查,由放射科医生评估。然而,这些医生通常聚焦于脊柱病变,可能忽略腹部异常,如恶性肿瘤。实际上,接受脊柱扫描的患者也可能存在肾上腺等腹腔脏器的病灶。为此,亟需计算机辅助筛查工具。本文以肾上腺可疑病变为例,提出多模型图聚合(MMGA)方法,利用轴向切片整合患者全量CT数据,自动判断是否存在肾上腺异常并定位。该方法包含三个深度学习模型,分别负责不同任务,构成复杂可复用的分析流程。本研究创新点在于:一是利用原本为脊柱成像优化的CT扫描,检测完全不同的腹腔病灶;二是构建可迁移的三模型架构,适用于胰腺、肾脏等其他器官或MRI等其他影像类型。
原文摘要 · Abstract (English)
Low back pain is the symptom that is the second most frequently reported to primary care physicians, effecting 50 to 80 percent of the population in a lifetime, resulting in multiple referrals of patients suffering from back problems, to CT and MRI scans, which are then examined by radiologists. The radiologists examining these spinal scans naturally focus on spinal pathologies and might miss other types of abnormalities, and in particular, abdominal ones, such as malignancies. Nevertheless, the patients whose spine was scanned might as well have malignant and other abdominal pathologies. Thus, clinicians have suggested the need for computerized assistance and decision support in screening spinal scans for additional abnormalities. In the current study, We have addressed the important case of detecting suspicious lesions in the adrenal glands as an example for the overall methodology we have developed. A patient CT scan is integrated from multiple slices with an axial orientation. Our method determines whether a patient has an abnormal adrenal gland, and localises the abnormality if it exists. Our method is composed of three deep learning models; each model has a different task for achieving the final goal. We call our compound method the Multi Model Graph Aggregation MMGA method. The novelty in this study is twofold. First, the use, for an important screening task, of CT scans that are originally focused and tuned for imaging the spine, which were acquired from patients with potential spinal disorders, for detection of a totally different set of abnormalities such as abdominal Adrenal glands pathologies. Second, we have built a complex pipeline architecture composed from three deep learning models that can be utilized for other organs (such as the pancreas or the kidney), or for similar applications, but using other types of imaging, such as MRI.
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