将小鼠神经元结构特性融入生成模型,提升对猫和奶酪图像的生成效果。
Murine AI excels at cats and cheese: Structural differences between human and mouse neurons and their implementation in generative AIs
- 在生成网络中模拟小鼠神经元更小的胞体和更细的突起结构。
- 小鼠类比模型在猫脸和奶酪图像生成上优于标准模型,但对人脸和鸟类表现较差。
- 模型偏好与小鼠认知特征一致,提示生物结构影响模型性能。
小鼠与人类大脑功能差异源于其神经网络结构。本研究分析了小鼠内侧前额叶皮层与人类前扣带回皮层的纳米级三维脑组织结构,发现小鼠神经元胞体更小、树突更细。这些特征使小鼠神经元可在有限脑容量内密集集成,但根据电缆理论,细突起应抑制远距离连接。我们将此小鼠类比约束引入生成对抗网络(GAN)和去噪扩散隐式模型(DDIM)的卷积层,在猫脸、奶酪、人脸和鸟类照片数据集上进行图像生成任务。结果表明,小鼠类比GAN在猫脸和奶酪数据集上优于标准GAN,但在人脸和鸟类数据集上表现较差;小鼠类比DDIM呈现相似趋势。分析显示四类数据集存在图像熵差异,可能影响生成所需参数量。小鼠类比AI的表现偏好与小鼠常见认知印象相符。未来应通过将更多生物学发现嵌入人工神经网络,探索神经网络结构与脑功能的关系。
原文摘要 · Abstract (English)
Mouse and human brains have different functions that depend on their neuronal networks. In this study, we analyzed nanometer-scale three-dimensional structures of brain tissues of the mouse medial prefrontal cortex and compared them with structures of the human anterior cingulate cortex. The obtained results indicated that mouse neuronal somata are smaller and neurites are thinner than those of human neurons. These structural features allow mouse neurons to be integrated in the limited space of the brain, though thin neurites should suppress distal connections according to cable theory. We implemented this mouse-mimetic constraint in convolutional layers of a generative adversarial network (GAN) and a denoising diffusion implicit model (DDIM), which were then subjected to image generation tasks using photo datasets of cat faces, cheese, human faces, and birds. The mouse-mimetic GAN outperformed a standard GAN in the image generation task using the cat faces and cheese photo datasets, but underperformed for human faces and birds. The mouse-mimetic DDIM gave similar results, suggesting that the nature of the datasets affected the results. Analyses of the four datasets indicated differences in their image entropy, which should influence the number of parameters required for image generation. The preferences of the mouse-mimetic AIs coincided with the impressions commonly associated with mice. The relationship between the neuronal network and brain function should be investigated by implementing other biological findings in artificial neural networks.
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