arXiv:2411.00840cs.LGcs.AI2024-11

用术前画钟测试+术中数据预测术后住院时长与死亡率

Peri-AIIMS: Perioperative Artificial Intelligence Driven Integrated Modeling of Surgeries using Anesthetic, Physical and Cognitive Statuses for Predicting Hospital Outcomes

  • 融合画钟测试图像特征与术中、人口统计学数据建模
  • 含认知特征的模型在12种手术-结局组合中表现最优
  • 适合关注围术期风险预测的临床医生和医疗AI研究者

术前认知状态与手术预后的关系是重要但研究不足的领域。将术中数据与术后结果关联,是评估手术长期影响的低成本途径。本研究评估了通过画钟测试衡量的术前认知状态,在预测住院时长、医院费用、随访期平均疼痛程度及1年死亡率方面,是否在已知术中变量、人口统计学、术前身体状况和合并症基础上仍具增量价值。分析扩展至6个特定手术组,并进行了交叉验证。画钟图像由半监督深度学习算法提取出10个结构化特征,该方法此前已被验证可区分痴呆与非痴呆患者。不同机器学习模型在独立测试集上进行训练与比较,评估其分类性能、时间复杂度与可解释性。采用SHAP分析识别不同手术情境下各类结局的最预测性特征。结果显示,包含画钟特征的围术期认知数据集在18种可能的手术-结局组合中,对其中12种表现最佳。

原文摘要 · Abstract (English)

The association between preoperative cognitive status and surgical outcomes is a critical, yet scarcely explored area of research. Linking intraoperative data with postoperative outcomes is a promising and low-cost way of evaluating long-term impacts of surgical interventions. In this study, we evaluated how preoperative cognitive status as measured by the clock drawing test contributed to predicting length of hospital stay, hospital charges, average pain experienced during follow-up, and 1-year mortality over and above intraoperative variables, demographics, preoperative physical status and comorbidities. We expanded our analysis to 6 specific surgical groups where sufficient data was available for cross-validation. The clock drawing images were represented by 10 constructional features discovered by a semi-supervised deep learning algorithm, previously validated to differentiate between dementia and non-dementia patients. Different machine learning models were trained to classify postoperative outcomes in hold-out test sets. The models were compared to their relative performance, time complexity, and interpretability. Shapley Additive Explanations (SHAP) analysis was used to find the most predictive features for classifying different outcomes in different surgical contexts. Relative classification performances achieved by different feature sets showed that the perioperative cognitive dataset which included clock drawing features in addition to intraoperative variables, demographics, and comorbidities served as the best dataset for 12 of 18 possible surgery-outcome combinations...

围术期预测认知评估机器学习画钟测试

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