arXiv:2411.01859eess.IVcs.CV2024-11被引 3

用脑功能信号增强纤维聚类,让白质分区更符合实际功能。

A Novel Deep Learning Tractography Fiber Clustering Framework for Functionally Consistent White Matter Parcellation Using Multimodal Diffusion MRI and Functional MRI

  • 融合扩散MRI几何信息与功能MRI信号,双视角学习纤维特征
  • 在真实数据上实现更符合神经功能的白质分区结果
  • 适合研究脑连接与功能关系的神经科学与医学研究人员

利用扩散MRI(dMRI)进行纤维聚类是白质(WM)分区的关键方法。现有方法主要依赖纤维的空间轨迹几何信息进行聚类,忽略了纤维路径上潜在的功能信号。近年研究表明,功能MRI(fMRI)可测量白质中的神经活动,为纤维聚类提供有价值的多模态信息。本文提出一种新型深度学习纤维聚类框架——深度多视图纤维聚类(DMVFC),通过联合使用dMRI和fMRI数据,实现功能一致的白质分区。DMVFC能有效整合白质纤维的几何特征与沿纤维路径的功能信号(BOLD)。该框架包含两个核心模块:1)多视图预训练模块,分别从纤维几何与功能信号中提取嵌入特征;2)协同微调模块,同步优化两类特征表示。实验表明,相较于两种先进的纤维聚类方法,DMVFC在生成功能有意义且一致的白质分区方面表现更优。

原文摘要 · Abstract (English)

Tractography fiber clustering using diffusion MRI (dMRI) is a crucial strategy for white matter (WM) parcellation. Current methods primarily use the geometric information of fibers (i.e., the spatial trajectories) to group similar fibers into clusters, overlooking the important functional signals present along the fiber tracts. There is increasing evidence that neural activity in the WM can be measured using functional MRI (fMRI), offering potentially valuable multimodal information for fiber clustering. In this paper, we develop a novel deep learning fiber clustering framework, namely Deep Multi-view Fiber Clustering (DMVFC), that uses joint dMRI and fMRI data to enable functionally consistent WM parcellation. DMVFC can effectively integrate the geometric characteristics of the WM fibers with the fMRI BOLD signals along the fiber tracts. It includes two major components: 1) a multi-view pretraining module to compute embedding features from fiber geometric information and functional signals separately, and 2) a collaborative fine-tuning module to simultaneously refine the two kinds of embeddings. In the experiments, we compare DMVFC with two state-of-the-art fiber clustering methods and demonstrate superior performance in achieving functionally meaningful and consistent WM parcellation results.

白质分区多模态融合功能连接

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