arXiv:2411.02843cs.CV2024-11被引 6

深度学习提升光声成像分辨率与速度,助力生物医学精准检测

Advances in Photoacoustic Imaging Reconstruction and Quantitative Analysis for Biomedical Applications

  • 融合传统与深度学习方法优化图像重建,减少伪影
  • 实现血红蛋白浓度与氧饱和度等生理参数定量分析
  • 适合医学影像、生物医学工程领域研究者参考

光声成像(PAI)是一种融合光学分辨率与声学穿透深度优势的新型生物医学成像技术,具有高安全性和广阔应用前景。然而,其临床应用仍面临穿透深度与空间分辨率之间的权衡,以及成像速度需求等挑战。本文系统探讨了光声计算机断层成像(PACT)、光声显微镜(PAM)和光声内窥成像(PAE)三种主要实现方式的基本原理,分析其优劣与实际限制。重点综述了在PACT、PAM和PAE中,采用传统或深度学习(DL)方法进行图像重建与伪影抑制的最新进展,显著提升了图像质量并加快了成像速度。同时,文章还总结了近年来在定量分析方面的突破,包括组织中血红蛋白浓度、氧饱和度及其他生理参数的精确量化。最后,展望了当前研究趋势与未来发展方向,强调深度学习在推动光声成像技术变革中的关键作用。

原文摘要 · Abstract (English)

Photoacoustic imaging (PAI) represents an innovative biomedical imaging modality that harnesses the advantages of optical resolution and acoustic penetration depth while ensuring enhanced safety. Despite its promising potential across a diverse array of preclinical and clinical applications, the clinical implementation of PAI faces significant challenges, including the trade-off between penetration depth and spatial resolution, as well as the demand for faster imaging speeds. This paper explores the fundamental principles underlying PAI, with a particular emphasis on three primary implementations: photoacoustic computed tomography (PACT), photoacoustic microscopy (PAM), and photoacoustic endoscopy (PAE). We undertake a critical assessment of their respective strengths and practical limitations. Furthermore, recent developments in utilizing conventional or deep learning (DL) methodologies for image reconstruction and artefact mitigation across PACT, PAM, and PAE are outlined, demonstrating considerable potential to enhance image quality and accelerate imaging processes. Furthermore, this paper examines the recent developments in quantitative analysis within PAI, including the quantification of haemoglobin concentration, oxygen saturation, and other physiological parameters within tissues. Finally, our discussion encompasses current trends and future directions in PAI research while emphasizing the transformative impact of deep learning on advancing PAI.

光声成像深度学习医学影像定量分析

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