提出对称动态学习框架,实现医学图像配准的拓扑保持与双向一致性。
A Symmetric Dynamic Learning Framework for Diffeomorphic Medical Image Registration
- 融合CNN-LSTM与同伦连续技术,分多尺度渐进修正正反向形变场。
- 在三个3D任务中优于现有方法,定量指标提升显著,视觉效果更优。
- 适合需要高精度、拓扑保持配准的临床影像分析场景。
微分同胚图像配准在医学影像应用中至关重要,因其能保持变换的拓扑结构。本文提出DCCNN-LSTM-Reg学习框架,通过满足特定控制增量系统,实现动态演化并学习对称配准路径,以获得移动图像与固定图像间的对称微分同胚变形。该框架将深度学习网络与微分同胚数学机制结合,构建连续动态的配准架构,包含五个不同尺度上级联的对称配准(SR)模块。具体地,首先使用两个参数共享的U-Net提取图像的多尺度特征金字塔;随后设计包含序列式CNN-LSTM结构的SR模块,利用控制增量学习和同伦连续技术逐步校正正反向多尺度形变场。在三个3D配准任务上的大量实验表明,该方法在定量和定性评估中均优于现有方法。
原文摘要 · Abstract (English)
Diffeomorphic image registration is crucial for various medical imaging applications because it can preserve the topology of the transformation. This study introduces DCCNN-LSTM-Reg, a learning framework that evolves dynamically and learns a symmetrical registration path by satisfying a specified control increment system. This framework aims to obtain symmetric diffeomorphic deformations between moving and fixed images. To achieve this, we combine deep learning networks with diffeomorphic mathematical mechanisms to create a continuous and dynamic registration architecture, which consists of multiple Symmetric Registration (SR) modules cascaded on five different scales. Specifically, our method first uses two U-nets with shared parameters to extract multiscale feature pyramids from the images. We then develop an SR-module comprising a sequential CNN-LSTM architecture to progressively correct the forward and reverse multiscale deformation fields using control increment learning and the homotopy continuation technique. Through extensive experiments on three 3D registration tasks, we demonstrate that our method outperforms existing approaches in both quantitative and qualitative evaluations.
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