公开新生儿缺氧缺血性脑病两年认知结局数据集，助力精准预后研究。
BOston Neonatal Brain Injury Data for Hypoxic Ischemic Encephalopathy (BONBID-HIE): II. 2-year Neurocognitive Outcome and NICU Outcome
- 构建包含237例患儿的多中心影像与临床数据集
- 覆盖新生儿重症监护室结局及2岁神经认知结果
- 为开发脑损伤生物标志物提供关键数据支持
全球约每1000名新生儿中有1至5例受缺氧缺血性脑病（HIE）影响，其中30%至50%在两岁时出现不良神经认知结局。尽管治疗性低温（TH）已取得进展，但预后仍具挑战性，亟需更优生物标志物。本文发布第二版波士顿新生儿脑损伤数据集（BONBID-HIE），为开源、综合性磁共振成像与临床数据集，涵盖来自麻省总医院和波士顿儿童医院的237名患者，包含新生儿重症监护室（NICU）结局及2岁神经认知结局信息。
原文摘要 · Abstract (English)
Hypoxic Ischemic Encephalopathy (HIE) affects approximately 1-5/1000 newborns globally and leads to adverse neurocognitive outcomes in 30% to 50% of cases by two years of age. Despite therapeutic advances with Therapeutic Hypothermia (TH), prognosis remains challenging, highlighting the need for improved biomarkers. This paper introduces the second release of the Boston Neonatal Brain Injury Dataset for Hypoxic-Ischemic Encephalopathy (BONBID-HIE), an open-source, comprehensive MRI and clinical dataset featuring 237 patients, including NICU outcomes and 2-year neurocognitive outcomes from Massachusetts General Hospital and Boston Children's Hospital.
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