用可解释注意力模型分析阴道镜图像,精准识别宫颈癌前病变风险。
An Explainable Attention Model for Cervical Precancer Risk Classification using Colposcopic Images
- 结合CBAM模块与可解释技术,提取图像关键特征并生成决策依据。
- 在独立测试和十折交叉验证中准确率分别达99.33%和99.81%。
- 对噪声和模糊有强鲁棒性,适合临床辅助诊断使用。
宫颈癌仍是全球重大健康问题,早期识别与风险评估对预防干预至关重要。本文提出Cervix-AID-Net模型,基于患者阴道镜图像进行宫颈癌前病变风险分类。模型融合卷积层与卷积块注意力模块(CBAM),提取可解释且具代表性的图像特征,以区分高风险与低风险病变。同时集成四种可解释性技术:梯度类激活图、局部可解释模型无关解释(LIME)、CartoonX以及基于输出特征与输入特征的像素率失真解释。通过留出集与十折交叉验证评估,模型分类准确率分别达到99.33%和99.81%。分析显示,CartoonX因能捕捉图像中分段平滑区域,提供更精细的决策解释。在输入添加高斯噪声≤3%或模糊程度≤10%时,性能保持不变;超过阈值后性能下降。与其它深度学习方法对比表明,该模型具有作为辅助工具提升宫颈癌前病变风险评估效率的潜力。结合CBAM与可解释人工智能集成的该方法,有望推动宫颈癌防治与早期筛查,改善患者预后并减轻全球疾病负担。
原文摘要 · Abstract (English)
Cervical cancer remains a major worldwide health issue, with early identification and risk assessment playing critical roles in effective preventive interventions. This paper presents the Cervix-AID-Net model for cervical precancer risk classification. The study designs and evaluates the proposed Cervix-AID-Net model based on patients colposcopy images. The model comprises a Convolutional Block Attention Module (CBAM) and convolutional layers that extract interpretable and representative features of colposcopic images to distinguish high-risk and low-risk cervical precancer. In addition, the proposed Cervix-AID-Net model integrates four explainable techniques, namely gradient class activation maps, Local Interpretable Model-agnostic Explanations, CartoonX, and pixel rate distortion explanation based on output feature maps and input features. The evaluation using holdout and ten-fold cross-validation techniques yielded a classification accuracy of 99.33\% and 99.81\%. The analysis revealed that CartoonX provides meticulous explanations for the decision of the Cervix-AID-Net model due to its ability to provide the relevant piece-wise smooth part of the image. The effect of Gaussian noise and blur on the input shows that the performance remains unchanged up to Gaussian noise of 3\% and blur of 10\%, while the performance reduces thereafter. A comparison study of the proposed model's performance compared to other deep learning approaches highlights the Cervix-AID-Net model's potential as a supplemental tool for increasing the effectiveness of cervical precancer risk assessment. The proposed method, which incorporates the CBAM and explainable artificial integration, has the potential to influence cervical cancer prevention and early detection, improving patient outcomes and lowering the worldwide burden of this preventable disease.
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