利用多分辨率图像自监督学习,减少标注数据需求,提升肾癌亚型分类准确率。
Renal Cell Carcinoma subtyping: learning from multi-resolution localization
- 基于组织切片多分辨率特性设计自监督训练策略
- 在全切片图像数据集上实现高精度肾癌亚型分类
- 适合资源有限但需高效病理诊断的医疗场景
肾细胞癌在早期常无症状,导致诊断延迟,治愈率低,死亡率相对较高。为提高生存率,快速准确地进行肿瘤亚型分类至关重要。当前基于人工智能的计算机辅助诊断方法虽具潜力,但受限于标注数据稀缺,难以有效训练监督学习模型。本研究提出一种新型自监督学习策略,充分利用组织病理切片的多分辨率特征,旨在减少对标注数据的依赖,同时保持诊断准确性。我们在全切片成像数据集上验证了该方法在肾癌亚型分类上的性能,并与多种先进分类模型进行对比,结果表明其具备优异的分类能力。
原文摘要 · Abstract (English)
Renal Cell Carcinoma is typically asymptomatic at the early stages for many patients. This leads to a late diagnosis of the tumor, where the curability likelihood is lower, and makes the mortality rate of Renal Cell Carcinoma high, with respect to its incidence rate. To increase the survival chance, a fast and correct categorization of the tumor subtype is paramount. Nowadays, computerized methods, based on artificial intelligence, represent an interesting opportunity to improve the productivity and the objectivity of the microscopy-based Renal Cell Carcinoma diagnosis. Nonetheless, much of their exploitation is hampered by the paucity of annotated dataset, essential for a proficient training of supervised machine learning technologies. This study sets out to investigate a novel self supervised training strategy for machine learning diagnostic tools, based on the multi-resolution nature of the histological samples. We aim at reducing the need of annotated dataset, without significantly reducing the accuracy of the tool. We demonstrate the classification capability of our tool on a whole slide imaging dataset for Renal Cancer subtyping, and we compare our solution with several state-of-the-art classification counterparts.
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