arXiv:2411.10479cs.LG2024-11综述被引 2

用问卷数据区分自闭症与多动症共病,机器学习效果有限但有潜力。

Challenges in the Differential Classification of Individual Diagnoses from Co-Occurring Autism and ADHD Using Survey Data

  • 基于全国儿童健康调查数据,用机器学习筛选行为特征。
  • 二分类模型准确率超92%,四分类模型敏感度仅65%以上。
  • 为儿童发育迟缓数字筛查提供新思路,适合临床辅助决策研究者。

自闭症和注意力缺陷多动障碍(ADHD)是儿童中最常见的神经发育障碍。在两者高共病背景下,区分单一诊断与共病状态仍具挑战性。本文利用美国国家儿童健康调查数据,训练机器学习模型识别可用于自动化临床决策支持系统的行为特征。针对‘发育迟缓(自闭症或ADHD)’ vs. ‘无发育迟缓’的二分类任务,模型达到敏感度>92%、特异性>94%;而针对‘自闭症’vs.‘ADHD’vs.‘两者均有’vs.‘均无’的四分类任务,敏感度>65%,特异性>66%。尽管二分类表现良好,但自闭症与ADHD的差异化分类性能仍较低,凸显当前临床决策工具在特异性上的局限。研究证明,非传统临床用途的行为问卷数据可为儿童发育迟缓的数字筛查提供支持。

原文摘要 · Abstract (English)

Autism and Attention-Deficit Hyperactivity Disorder (ADHD) are two of the most commonly observed neurodevelopmental conditions in childhood. Providing a specific computational assessment to distinguish between the two can prove difficult and time intensive. Given the high prevalence of their co-occurrence, there is a need for scalable and accessible methods for distinguishing the co-occurrence of autism and ADHD from individual diagnoses. The first step is to identify a core set of features that can serve as the basis for behavioral feature extraction. We trained machine learning models on data from the National Survey of Children's Health to identify behaviors to target as features in automated clinical decision support systems. A model trained on the binary task of distinguishing either developmental delay (autism or ADHD) vs. neither achieved sensitivity >92% and specificity >94%, while a model trained on the 4-way classification task of autism vs. ADHD vs. both vs. none demonstrated >65% sensitivity and >66% specificity. While the performance of the binary model was respectable, the relatively low performance in the differential classification of autism and ADHD highlights the challenges that persist in achieving specificity within clinical decision support tools for developmental delays. Nevertheless, this study demonstrates the potential of applying behavioral questionnaires not traditionally used for clinical purposes towards supporting digital screening assessments for pediatric developmental delays.

自闭症ADHD机器学习数字筛查

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