通过k空间配准提升脑部磁敏感成像的重复性，更易发现早期神经退行性病变。
Improving the Test-retest Reliability of Quantitative Susceptibility Mapping
- 在k空间用非均匀快速傅里叶变换对齐不同扫描协议的相位与幅值图像
- 多协议扫描的测试-重测可靠性显著提升，降低采集参数带来的偏差
- 适合研究阿尔茨海默病、帕金森病等早期脑部病变的影像学分析
动机：磁敏感成像（QSM）的测试-重测可靠性受扫描协议参数影响，如采集平面与主磁场方向夹角及空间分辨率。目标：减少因扫描协议差异导致的系统性偏差，避免病理引起的微小磁化率变化被掩盖。方法：利用非均匀快速傅里叶变换（NUFFT）在k空间对各协议的幅值和相位图像进行标准化配准。结果：所提方法显著提升了不同协议间扫描的测试-重测一致性。影响：改进后的QSM可靠性有助于在阿尔茨海默病、帕金森病等神经退行性疾病早期阶段更灵敏地检测微小磁化率变化。
原文摘要 · Abstract (English)
Motivation - The test-retest reliability of quantitative susceptibility mapping (QSM) is affected by parameters of the acquisition protocol such as the angulation of acquisition plane with respect to the B0 field direction and spatial resolution. Goal - We aim to reduce the protocol-dependent biases/errors that might overshadow subtle changes of the susceptibility values due to pathology in the brain. Approach - The magnitude and phase images used for QSM are registered according to a standard reference protocol in the k-space through nonuniform fast Fourier transform (NUFFT). Results - With the help of our proposed approach, the test-retest reliability of scans acquired from different protocols is notably improved. Impact - The improved test-retest reliability of QSM makes it easier to detect subtle susceptibility changes in the early stages of neurodegeneration such as Alzheimer's disease and Parkinson's disease.
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