多尺度级联网络精准分割全身关键器官,提升放疗手术安全性。
Multi-scale Cascaded Foundation Model for Whole-body Organs-at-risk Segmentation
- 构建多尺度级联融合网络,分阶段强化特征提取与融合
- 在10个数据集上实现稳定高精度分割,低分辨率输入仍表现可靠
- 适合医学影像智能分析、放疗辅助诊断等临床场景
准确分割关键器官(OARs)对安全精准的放射治疗和手术至关重要。现有研究大多仅针对有限器官或区域,缺乏系统性方案。本文提出多尺度级联融合网络(MCFNet),通过多尺度特征聚合提升表征能力。MCFNet包含锐化提取主干(用于下采样路径)和灵活连接主干(用于跳跃连接融合),在两个阶段均增强表示学习。该设计改善了边界定位,保留细粒结构,同时保持计算高效,支持低分辨率输入下的可靠性能。在671名患者共36,131张图像-掩码对(覆盖10个数据集)上,使用NVIDIA A6000 GPU进行实验,结果表明其具有强鲁棒性和跨数据集泛化能力。自适应损失聚合策略进一步稳定优化过程,提升准确率与训练效率。大量验证显示,MCFNet优于现有方法,在器官分割任务中表现优异,为计算机辅助诊断提供可靠影像支持。本方案旨在提升放疗与手术的精准度和安全性,推动个性化治疗发展。代码已开源:https://github.com/Henry991115/MCFNet。
原文摘要 · Abstract (English)
Accurate segmentation of organs-at-risk (OARs) is vital for safe and precise radiotherapy and surgery. Most existing studies segment only a limited set of organs or regions, lacking a systematic treatment of OARs segmentation. We present a Multi-scale Cascaded Fusion Network (MCFNet) that aggregates features across multiple scales and resolutions. MCFNet consists of a Sharp Extraction Backbone for the downsampling path and a Flexible Connection Backbone for skip-connection fusion, strengthening representation learning in both stages. This design improves boundary localization and preserves fine structures while maintaining computational efficiency, enabling reliable performance even on low-resolution inputs. Experiments on an NVIDIA A6000 GPU using 36,131 image-mask pairs from 671 patients across 10 datasets show consistent robustness and strong cross-dataset generalization. An adaptive loss-aggregation strategy further stabilizes optimization and yields additional gains in accuracy and training efficiency. Through extensive validation, MCFNet outperforms existing methods, excelling in organ segmentation and providing reliable image-guided support for computer-aided diagnosis. Our solution aims to improve the precision and safety of radiotherapy and surgery while supporting personalized treatment, advancing modern medical technology. The code has been made available on GitHub: https://github.com/Henry991115/MCFNet.
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