对比扩散模型在病理图像生成中的表现,发现其能高效生成高质量数据。
Comparative Analysis of Diffusion Generative Models in Computational Pathology
- 采用多尺度视野数据对比不同扩散模型生成效果
- 调整图像尺寸可模拟不同视野,提升数据多样性
- 适合用于增强病理图像数据集,提升模型精度
扩散生成模型(DGM)在计算机视觉领域迅速兴起,因其生成样本质量高、模式覆盖广而备受关注。尽管计算开销大,仍被广泛应用于深度学习各类任务。然而,在计算病理学及大规模病理数据集上的研究相对滞后。本文针对病理数据的复杂性,对多种扩散模型在病理数据集上的表现进行深入比较分析。研究涵盖不同视野(FOV)的数据集,结果表明DGM能有效生成高质量合成图像。通过消融实验,详细探讨了不同方法对生成的组织病理图像的影响。一个关键发现是:生成时调整图像尺寸可模拟不同视野效果。这些成果凸显了DGM在提升合成病理数据质量和多样性方面的潜力,尤其在与真实数据结合使用时,有助于提高深度学习模型在组织病理学中的准确率。代码已公开于https://github.com/AtlasAnalyticsLab/Diffusion4Path。
原文摘要 · Abstract (English)
Diffusion Generative Models (DGM) have rapidly surfaced as emerging topics in the field of computer vision, garnering significant interest across a wide array of deep learning applications. Despite their high computational demand, these models are extensively utilized for their superior sample quality and robust mode coverage. While research in diffusion generative models is advancing, exploration within the domain of computational pathology and its large-scale datasets has been comparatively gradual. Bridging the gap between the high-quality generation capabilities of Diffusion Generative Models and the intricate nature of pathology data, this paper presents an in-depth comparative analysis of diffusion methods applied to a pathology dataset. Our analysis extends to datasets with varying Fields of View (FOV), revealing that DGMs are highly effective in producing high-quality synthetic data. An ablative study is also conducted, followed by a detailed discussion on the impact of various methods on the synthesized histopathology images. One striking observation from our experiments is how the adjustment of image size during data generation can simulate varying fields of view. These findings underscore the potential of DGMs to enhance the quality and diversity of synthetic pathology data, especially when used with real data, ultimately increasing accuracy of deep learning models in histopathology. Code is available from https://github.com/AtlasAnalyticsLab/Diffusion4Path
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