将3D血管图谱自动配准到2D DSA，实现出血区域精准定量分析。
Automated Registration of 3D Neurovascular Territory Atlas to 2D DSA for Targeted Quantitative Angiography Analysis
- 用3D血管图谱与2D DSA图像配准，定位关键供血区。
- 通过可变形配准使图谱与DSA灌注区重合度提升，SSIM值显著提高。
- 适合介入手术中需要精准评估脑血管的临床场景。
蛛网膜下腔出血（SAH）常由颅内动脉瘤引起，需精确影像支持治疗。数字减影血管造影（DSA）虽为金标准，但仅能粗略显示脑血流，可能掩盖关键细节。本研究提出一种将3D血管图谱与2D DSA图像融合的方法，实现对关键供血区的靶向定量分析，提升术中诊断精度。首先确定造影注射部位，再选定对应视角对齐3D图谱；随后基于DSA序列生成灌注区掩码，用于粗略对齐3D图谱投影。进一步采用可变形配准技术实现图谱与实际灌注区的精确叠加。通过结构相似性指数（SSIM）评估配准效果，结果表明可变形配准对实现高精度重叠至关重要。该方法可提取特定区域的定量血管参数，助力复杂SAH病例的精细化评估。3D图谱与2D DSA投影的整合，提升了术中诊断的准确性与靶向性，增强可视化能力，有助于临床决策。
原文摘要 · Abstract (English)
Subarachnoid hemorrhage (SAH), typically due to intracranial aneurysms, demands precise imaging for effective treatment. Digital Subtraction Angiography (DSA), despite being the gold standard, broadly visualizes cerebral blood flow, potentially masking key details in areas. This study introduces an approach integrating a 3D vascular atlas with 2D DSA images to allow targeted quantitative analysis in these crucial regions, thus enhancing diagnostic accuracy during interventions. Initially, DSA data was examined to ascertain the injection site. Following this, the appropriate viewing angle was determined to align accurately with the 3D vascular atlas. Utilizing this atlas, regions corresponding to the areas indicated as perfused were selected. Concurrently, a mask representing the perfused areas was created from the DSA sequence. This mask facilitated the initial coarse alignment of the projected 3D atlas to the DSA perfused territory deformable registration techniques, ensuring a precise overlay with the DSAs perfused territories. The performance of each overlay was measured using the Structural Similarity Index Measure (SSIM). The coregistration process revealed that deformable registrations was essential to achieve precise overlays of the 3D atlas projections with the 2D DSA perfused areas. This approach enabled the extraction of targeted quantitative angiography parameters, essential for detailed vascular assessment in subarachnoid hemorrhage cases. The integration of 3D atlas registration with 2D DSA projections facilitates a more precise and targeted diagnostic process for SAH during critical interventions. This image processing strategy enhances the visualization of affected arterial territories, potentially improving the accuracy of diagnostics and supporting better informed clinical decisions at the time of intervention
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