arXiv:2412.02859cs.ROcs.SY2024-12

用新型磁驱动方法精准操控磁性液滴,适用于微流控芯片等场景。

Novel Magnetic Actuation Strategies for Precise Ferrofluid Marble Manipulation in Magnetic Digital Microfluidics: Position Control and Applications

  • 结合亥姆霍兹线圈与永磁体,提出三种磁力调控策略。
  • 实验验证可实现双液滴同步控制与非磁性液滴运输,功耗低、响应快。
  • 适合微流控系统、药物递送等需高精度液滴操作的领域。

精确操控液滴在实验室芯片、药物递送和生物技术等领域具有重要应用价值,但长期面临挑战。磁性液滴(Ferrofluid Marble, FM)因内核含磁流体,可被磁场便捷操控,但此前在磁数字微流控中尚未实现精准控制。本研究首次提出一种基于亥姆霍兹线圈与永磁体组合的新型磁驱动方法,推导了控制FM位置的控制方程,揭示了三种不同的磁力调节策略。通过实验对比不同磁构型在多种频率下的能量消耗与跟踪性能,验证了该方法的有效性。展示了多项应用:可控往返定位、双FM同步控制、利用FM搬运非磁性液滴,以及从FM液芯中提取样品的创新方法。

原文摘要 · Abstract (English)

Precise manipulation of liquid marbles has significant potential in various applications such as lab-on-a-chip systems, drug delivery, and biotechnology and has been a challenge for researchers. Ferrofluid marble (FM) is a marble with a ferrofluid core that can easily be manipulated by a magnetic field. Although FMs have great potential for accurate positioning and manipulation, these marbles have not been precisely controlled in magnetic digital microfluidics, so far. In this study for the first time, a novel method of magnetic actuation is proposed using a pair of Helmholtz coils and permanent magnets. The governing equations for controlling the FM position are investigated, and it is shown that there are three different strategies for adjusting the applied magnetic force. Then, experiments are conducted to demonstrate the capability of the proposed method. To this aim, different magnetic setups are proposed for manipulating FMs. These setups are compared in terms of energy consumption and tracking ability across various frequencies. The study showcases several applications of precise FM position control, including controllable reciprocal positioning, simultaneous position control of two FMs, the transport of non-magnetic liquid marbles using the FMs, and sample extraction method from the liquid core of the FM.

微流控磁驱动液滴操控生物芯片

Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。