arXiv:2412.03081eess.IV2024-12被引 1

用时间衰减注意力模型,结合影像特征与动态风险预测,提升乳腺癌短期风险评估精度。

A new Time-decay Radiomics Integrated Network (TRINet) for short-term breast cancer risk prediction

  • 引入时间衰减注意力机制,优先关注近期乳腺钼靶影像。
  • 在1-5年预测中AUC最高达0.851,显著优于现有模型。
  • 适合需要个性化筛查方案的临床医生和健康管理人群。

为促进乳腺癌早期发现,亟需开发可制定个体化筛查方案的短期风险预测方法。本文提出新型深度学习架构TRINet,通过时间衰减注意力机制聚焦近期乳腺钼靶检查,弥补现有模型忽视新图像重要性的缺陷。该模型融合放射组学特征与基于注意力的多实例学习(AMIL)框架,综合多视角信息以优化风险估计。同时,引入基于双侧不对称性的新标签分配策略,结合持续学习机制,增强模型对不对称癌症征兆的适应性。最后,通过嵌入时间信息的加性风险层,实现基于个体筛查间隔的动态多年度风险预测。实验使用美国EMBED数据集(8,528例)和瑞典CSAW数据集(8,723例)。EMBED测试集结果显示,本方法在1至5年预测窗口的AUC分别为0.851、0.811、0.796、0.793和0.789,显著优于当前最优模型。结果表明,整合时间注意力、放射组学特征、时间嵌入、双侧不对称性及持续学习策略,可构建更自适应、更精准的短期乳腺癌风险预测工具。

原文摘要 · Abstract (English)

To facilitate early detection of breast cancer, there is a need to develop short-term risk prediction schemes that can prescribe personalized/individualized screening mammography regimens for women. In this study, we propose a new deep learning architecture called TRINet that implements time-decay attention to focus on recent mammographic screenings, as current models do not account for the relevance of newer images. We integrate radiomic features with an Attention-based Multiple Instance Learning (AMIL) framework to weigh and combine multiple views for better risk estimation. In addition, we introduce a continual learning approach with a new label assignment strategy based on bilateral asymmetry to make the model more adaptable to asymmetrical cancer indicators. Finally, we add a time-embedded additive hazard layer to perform dynamic, multi-year risk forecasting based on individualized screening intervals. We used two public datasets, namely 8,528 patients from the American EMBED dataset and 8,723 patients from the Swedish CSAW dataset in our experiments. Evaluation results on the EMBED test set show that our approach significantly outperforms state-of-the-art models, achieving AUC scores of 0.851, 0.811, 0.796, 0.793, and 0.789 across 1-, 2-, to 5-year intervals, respectively. Our results underscore the importance of integrating temporal attention, radiomic features, time embeddings, bilateral asymmetry, and continual learning strategies, providing a more adaptive and precise tool for short-term breast cancer risk prediction.

乳腺癌风险预测时间注意力放射组学

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