用LSTM自动识别帕金森患者步态冻结,准确率达97.7%
Parkinson's Disease Diagnosis Through Deep Learning: A Novel LSTM-Based Approach for Freezing of Gait Detection
- 基于LSTM构建时序模型,自动捕捉步态长期依赖关系
- 在Physionet数据集上达到99%敏感度与97.71%准确率
- 无需人工特征工程,适合临床早期筛查应用
深度学习在医疗领域具有巨大潜力,可从大规模临床数据中挖掘隐藏模式,辅助疾病诊断。帕金森病(PD)是一种神经退行性疾病,其早期阶段因患者与健康人行为相似,难以实现自动诊断。本文提出一种基于LSTM的新型深度学习架构,用于自动检测帕金森患者步态冻结(FOG)事件。相比传统机器学习算法,该方法避免了手动特征工程,有效捕捉步态中的长时序依赖关系。LSTM通过记忆单元替代自连接隐藏层,缓解梯度消失问题,提升信息吸收能力。为防止过拟合,采用丢弃法(dropout)和L2正则化,并使用Adam优化器进行训练。实验结果表明,该方法在Physionet的VGRF步态信号数据集上,对步态冻结事件的检测准确率达到97.71%,敏感度99%,精确度98%,特异度96%,优于当前主流模型,展现出在帕金森病早期诊断中的优越性能。
原文摘要 · Abstract (English)
Deep learning holds tremendous potential in healthcare for uncovering hidden patterns within extensive clinical datasets, aiding in the diagnosis of various diseases. Parkinson's disease (PD) is a neurodegenerative condition characterized by the deterioration of brain function. In the initial stages of PD, automatic diagnosis poses a challenge due to the similarity in behavior between individuals with PD and those who are healthy. Our objective is to propose an effective model that can aid in the early detection of Parkinson's disease. We employed the VGRF gait signal dataset sourced from Physionet for distinguishing between healthy individuals and those diagnosed with Parkinson's disease. This paper introduces a novel deep learning architecture based on the LSTM network for automatically detecting freezing of gait episodes in Parkinson's disease patients. In contrast to conventional machine learning algorithms, this method eliminates manual feature engineering and proficiently captures prolonged temporal dependencies in gait patterns, thereby improving the diagnosis of Parkinson's disease. The LSTM network resolves the issue of vanishing gradients by employing memory blocks in place of self-connected hidden units, allowing for optimal information assimilation. To prevent overfitting, dropout and L2 regularization techniques have been employed. Additionally, the stochastic gradient-based optimizer Adam is used for the optimization process. The results indicate that our proposed approach surpasses current state-of-the-art models in FOG episode detection, achieving an accuracy of 97.71%, sensitivity of 99%, precision of 98%, and specificity of 96%. This demonstrates its potential as a superior classification method for Parkinson's disease detection.
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