用长视域特征融合网络提升脑电/脑磁图癫痫尖波自动识别准确率
LV-CadeNet: A Long-View Feature Convolution-Attention Fusion Encoder-Decoder Network for EEG/MEG Spike Analysis
- 设计长视域特征表示,结合局部尖波与上下文模式分析
- 在脑电数据集上分类准确率超越6个主流方法,在脑磁图数据上提升13.58%平衡准确率
- 适合神经科医生和脑电信号算法研究者使用
脑电图(EEG)或脑磁图(MEG)中间发作性痫样放电(IED)的分析是癫痫诊断的关键环节。然而,人工从大量数据中识别这些表现为癫痫尖波的IED耗时且需高专业水平。尽管已有自动化方法,但现有技术在两点上未能模拟临床专家判断:一是仅分析与单个尖波持续时间匹配的短时窗信号,忽略临床医生常用的扩展上下文模式;二是未能充分捕捉相邻传感器上同时存在的正负电位分布的偶极子特征,而这是临床判读IED的关键依据。为此,我们提出新型深度学习框架LV-CadeNet,集成两项创新:(1) 长视域形态学特征表示,模仿临床专家对局部尖波特征与长期上下文信息的综合评估;(2) 分层编码器-解码器网络,采用卷积-注意力模块实现多尺度时空特征学习与逐步抽象。大量实验验证其优越性能:在最大公开脑电尖波数据集TUEV上,优于六个先进方法;在首都医科大学三博脑科医院临床脑磁图数据集上,平衡准确率相较最优基线提升13.58%。
原文摘要 · Abstract (English)
The analysis of interictal epileptiform discharges (IEDs) in magnetoencephalography (MEG) or electroencephalogram (EEG) recordings represents a critical component in the diagnosis of epilepsy. However, manual analysis of these IEDs, which appear as epileptic spikes, from the large amount of MEG/EEG data is labor intensive and requires high expertise. Although automated methods have been developed to address this challenge, current approaches fail to fully emulate clinical experts' diagnostic intelligence in two key aspects: (1) their analysis on the input signals is limited to short temporal windows matching individual spike durations, missing the extended contextual patterns clinicians use to assess significance; and (2) they fail to adequately capture the dipole patterns with simultaneous positive-negative potential distributions across adjacent sensors that serve as clinicians' key diagnostic criterion for IED identification. To bridge this artificial-human intelligence gap, we propose a novel deep learning framework LV-CadeNet that integrates two key innovations: (1) a Long-View morphological feature representation that mimics expert clinicians' comprehensive assessment of both local spike characteristics and long-view contextual information, and (2) a hierarchical Encoder-Decoder NETwork that employs Convolution-Attention blocks for multi-scale spatiotemporal feature learning with progressive abstraction. Extensive evaluations confirm the superior performance of LV-CadeNet, which outperforms six state-of-the-art methods in EEG spike classification on TUEV, the largest public EEG spike dataset. Additionally, LV-CadeNet attains a significant improvement of 13.58% in balanced accuracy over the leading baseline for MEG spike detection on a clinical MEG dataset from Sanbo Brain Hospital, Capital Medical University.
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