解决动态样本成像时的运动伪影问题，提升光学断层成像精度
Space-time inverse-scattering of translation-based motion
- 联合优化运动位置与三维折射率分布，同步补偿平移运动
- 实验显示伪影减少、空间分辨率提升、定量精度更高
- 适合对运动样本进行高精度光学成像的研究者使用
在光学衍射断层成像（ODT）中，通常假设样品在多角度照明过程中保持静止以重建其三维折射率（RI）。当样品在此期间发生动态运动，会导致显著伪影和失真，降低重建图像质量。本文提出一种时空反散射技术，用于补偿多散射样品在数据采集过程中的平移运动。该方法构建联合优化问题，同时估计每个测量时刻的样品平移位置及其运动校正后的3D RI分布。实验结果表明，该方法可有效减少伪影，提升空间分辨率，并改善连续平移运动下样品的定量准确性。
原文摘要 · Abstract (English)
In optical diffraction tomography (ODT), a sample's 3D refractive-index (RI) is often reconstructed after illuminating it from multiple angles, with the assumption that the sample remains static throughout data collection. When the sample undergoes dynamic motion during this data-collection process, significant artifacts and distortions compromise the fidelity of the reconstructed images. In this study, we develop a space-time inverse-scattering technique for ODT that compensates for the translational motion of multiple-scattering samples during data collection. Our approach involves formulating a joint optimization problem to simultaneously estimate a scattering sample's translational position at each measurement and its motion-corrected 3D RI distribution. Experimental results demonstrate the technique's effectiveness, yielding reconstructions with reduced artifacts, enhanced spatial resolution, and improved quantitative accuracy for samples undergoing continuous translational motion during imaging.
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