用胸部X光和电子病历数据,用深度学习提前筛查糖尿病。
Deep Learning-Based Noninvasive Screening of Type 2 Diabetes with Chest X-ray Images and Electronic Health Records
- 融合胸部X光、电子病历等多模态数据,用深度模型自动提取特征。
- 模型在9863个样本上达到0.86的AUROC,比单用X光提升2.3%。
- 适合做医学影像与健康数据融合研究的学者参考。
2型糖尿病(T2DM)因早期无症状且依赖低效的临床检测手段,导致全球广泛流行。现有非侵入性筛查工具虽有进展,但传统机器学习受限于单一数据模态,需大量人工特征工程。相比之下,深度学习可整合多模态数据实现更全面的健康评估。然而,作为最常见医疗检查之一的胸部X线(CXR),其潜力尚未被充分挖掘。本研究评估了将CXR图像与电子健康记录(EHRs)及心电图信号相结合用于T2DM检测的可行性。基于MIMIC-IV数据库构建的数据集,我们探索了两种深度融合范式:基于早期融合的多模态Transformer与模块化联合融合的ResNet-LSTM架构。端到端训练的ResNet-LSTM模型达到0.86的AUROC,仅用9863个训练样本即较仅使用CXR的基线提升2.3%。结果表明,CXR在多模态框架中具备显著诊断价值,可用于早期识别高风险人群。此外,数据预处理流程已公开,以支持该领域进一步研究。
原文摘要 · Abstract (English)
The imperative for early detection of type 2 diabetes mellitus (T2DM) is challenged by its asymptomatic onset and dependence on suboptimal clinical diagnostic tests, contributing to its widespread global prevalence. While research into noninvasive T2DM screening tools has advanced, conventional machine learning approaches remain limited to unimodal inputs due to extensive feature engineering requirements. In contrast, deep learning models can leverage multimodal data for a more holistic understanding of patients' health conditions. However, the potential of chest X-ray (CXR) imaging, one of the most commonly performed medical procedures, remains underexplored. This study evaluates the integration of CXR images with other noninvasive data sources, including electronic health records (EHRs) and electrocardiography signals, for T2DM detection. Utilising datasets meticulously compiled from the MIMIC-IV databases, we investigated two deep fusion paradigms: an early fusion-based multimodal transformer and a modular joint fusion ResNet-LSTM architecture. The end-to-end trained ResNet-LSTM model achieved an AUROC of 0.86, surpassing the CXR-only baseline by 2.3% with just 9863 training samples. These findings demonstrate the diagnostic value of CXRs within multimodal frameworks for identifying at-risk individuals early. Additionally, the dataset preprocessing pipeline has also been released to support further research in this domain.
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