用AI团队辅助罕见病诊疗,效果超越现有模型。
RareAgents: Autonomous Multi-disciplinary Team for Rare Disease Diagnosis and Treatment
- 构建多学科AI团队协同诊断,整合记忆与医疗工具。
- 在罕见病诊疗中表现优于GPT-4o和主流模型。
- 适合医学AI研究者与罕见病临床支持系统开发者。
罕见病虽单个发病率低,但全球累计影响约3亿人,因涉及多器官系统且专科医生稀缺,诊疗难度远超常见病。近期基于大语言模型(LLMs)的智能体在多个领域展现潜力,部分方法在医学问答任务中已超越直接提示。然而,现有智能体框架难以适应真实临床场景,尤其复杂罕见病需求。为此,我们提出RareAgents,首个专为罕见病复杂临床环境设计的LLM驱动多学科团队决策支持工具。该系统融合多学科团队(MDT)协作、记忆机制与医疗工具调用,以Llama-3.1-8B/70B为基础模型。实验表明,RareAgents在罕见病诊断与治疗任务中,优于当前最先进的领域模型、GPT-4o及主流智能体框架。此外,我们还构建了新型罕见病数据集MIMIC-IV-Ext-Rare,以推动该领域研究发展。
原文摘要 · Abstract (English)
Rare diseases, despite their low individual incidence, collectively impact around 300 million people worldwide due to the vast number of diseases. The involvement of multiple organs and systems, and the shortage of specialized doctors with relevant experience, make diagnosing and treating rare diseases more challenging than common diseases. Recently, agents powered by large language models (LLMs) have demonstrated notable applications across various domains. In the medical field, some agent methods have outperformed direct prompts in question-answering tasks from medical examinations. However, current agent frameworks are not well-adapted to real-world clinical scenarios, especially those involving the complex demands of rare diseases. To bridge this gap, we introduce RareAgents, the first LLM-driven multi-disciplinary team decision-support tool designed specifically for the complex clinical context of rare diseases. RareAgents integrates advanced Multidisciplinary Team (MDT) coordination, memory mechanisms, and medical tools utilization, leveraging Llama-3.1-8B/70B as the base model. Experimental results show that RareAgents outperforms state-of-the-art domain-specific models, GPT-4o, and current agent frameworks in diagnosis and treatment for rare diseases. Furthermore, we contribute a novel rare disease dataset, MIMIC-IV-Ext-Rare, to facilitate further research in this field.
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