用扩散模型从非侵入性眼底图生成荧光造影图，解决数据少、病种多难题。

Fundus imaging is a critical tool in ophthalmology, with different imaging modalities offering unique advantages. For instance, fundus fluorescein angiography (FFA) can accurately identify eye diseases. However, traditional invasive FFA involves the injection of sodium fluorescein, which can cause discomfort and risks. Generating corresponding FFA images from non-invasive fundus images holds significant practical value but also presents challenges. First, limited datasets constrain the performance and effectiveness of models. Second, previous studies have primarily focused on generating FFA for single diseases or single modalities, often resulting in poor performance for patients with various ophthalmic conditions. To address these issues, we propose a novel latent diffusion model-based framework, Diffusion, which introduces a fine-tuning protocol to overcome the challenge of limited medical data and unleash the generative capabilities of diffusion models. Furthermore, we designed a new approach to tackle the challenges of generating across different modalities and disease types. On limited datasets, our framework achieves state-of-the-art results compared to existing methods, offering significant potential to enhance ophthalmic diagnostics and patient care. Our code will be released soon to support further research in this field.