arXiv:2412.15412cs.LG2024-12被引 2

用脑电图自动分鼠睡眠阶段,效果优于传统方法。

LG-Sleep: Local and Global Temporal Dependencies for Mice Sleep Scoring

  • 结合局部与全局时间特征,用卷积+LSTM捕捉脑电信号变化。
  • 在有限样本下仍能准确识别清醒、快眼动和非快眼动睡眠。
  • 无需针对个体训练,适合跨鼠种推广,适用于小样本研究。

高效识别睡眠阶段对理解动物及临床睡眠机制至关重要。人工评分耗时且依赖专业经验,促使自动化方法兴起。小鼠睡眠研究对理解睡眠模式与障碍具有重要意义,亟需可靠评分技术。本文提出LG-Sleep,一种新型无个体依赖的深度神经网络架构,基于脑电图(EEG)信号实现小鼠睡眠分期。该模型通过提取EEG信号中的局部与全局时间动态,将睡眠分为清醒、快速眼动(REM)和非快速眼动(NREM)三个阶段。其采用时序分布卷积网络捕捉局部时间变化,再通过长短期记忆(LSTM)模块提取长期依赖关系。模型以自编码器-解码器方式优化,增强跨个体泛化能力,适应小样本训练。实验表明,相比传统深度网络,LG-Sleep性能更优,即使在少量训练数据下也保持良好表现。

原文摘要 · Abstract (English)

Efficiently identifying sleep stages is crucial for unraveling the intricacies of sleep in both preclinical and clinical research. The labor-intensive nature of manual sleep scoring, demanding substantial expertise, has prompted a surge of interest in automated alternatives. Sleep studies in mice play a significant role in understanding sleep patterns and disorders and underscore the need for robust scoring methodologies. In response, this study introduces LG-Sleep, a novel subject-independent deep neural network architecture designed for mice sleep scoring through electroencephalogram (EEG) signals. LG-Sleep extracts local and global temporal transitions within EEG signals to categorize sleep data into three stages: wake, rapid eye movement (REM) sleep, and non-rapid eye movement (NREM) sleep. The model leverages local and global temporal information by employing time-distributed convolutional neural networks to discern local temporal transitions in EEG data. Subsequently, features derived from the convolutional filters traverse long short-term memory blocks, capturing global transitions over extended periods. Crucially, the model is optimized in an autoencoder-decoder fashion, facilitating generalization across distinct subjects and adapting to limited training samples. Experimental findings demonstrate superior performance of LG-Sleep compared to conventional deep neural networks. Moreover, the model exhibits good performance across different sleep stages even when tasked with scoring based on limited training samples.

睡眠分期深度学习脑电图小鼠研究

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