arXiv:2412.16118physics.med-phcs.AI2024-12中稿 · AAAI被引 3

用深度网络快速预测脊髓复杂结构中的聚焦超声波传播,实现毫秒级精准计算。

Convolutional Deep Operator Networks for Learning Nonlinear Focused Ultrasound Wave Propagation in Heterogeneous Spinal Cord Anatomy

  • 基于卷积DeepONet学习超声波在异质脊髓中的非线性传播规律
  • 测试集误差仅2%,推理速度达实时级别(相比小时级仿真)
  • 适合神经外科术中快速评估不同探头位置的治疗效果

聚焦超声(FUS)疗法有望实现脊髓损伤(SCI)的精准治疗,可在亚毫米精度下促进损伤部位血流,同时最小化对周围组织的影响。然而,其疗效高度依赖超声源位置,因脊髓复杂几何结构和声学异质性会导致超声信号畸变与衰减。现有方法依赖计算机仿真求解控制波动方程,结合脊髓超声图像生成患者特异性压力图,虽准确但计算量大,参数扫描需数小时,难以用于实时手术决策。为此,本文提出一种卷积深度算子网络(DeepONet),可快速预测患者脊髓内的FUS压力场。与传统神经网络不同,DeepONets擅长逼近参数化偏微分方程(PDEs)的解算子,在不同初始/边界条件(如新探头位置或脊髓几何)下无需大量仿真即可预测。该模型在多种患者解剖结构的模拟压力图上训练,测试集损失仅2%,显著加速了异质域中非线性物理系统的建模。本工作为神经外科手术中实现快速参数扫描提供了关键技术支撑,推动个体化精准治疗落地。

原文摘要 · Abstract (English)

Focused ultrasound (FUS) therapy is a promising tool for optimally targeted treatment of spinal cord injuries (SCI), offering submillimeter precision to enhance blood flow at injury sites while minimizing impact on surrounding tissues. However, its efficacy is highly sensitive to the placement of the ultrasound source, as the spinal cord's complex geometry and acoustic heterogeneity distort and attenuate the FUS signal. Current approaches rely on computer simulations to solve the governing wave propagation equations and compute patient-specific pressure maps using ultrasound images of the spinal cord anatomy. While accurate, these high-fidelity simulations are computationally intensive, taking up to hours to complete parameter sweeps, which is impractical for real-time surgical decision-making. To address this bottleneck, we propose a convolutional deep operator network (DeepONet) to rapidly predict FUS pressure fields in patient spinal cords. Unlike conventional neural networks, DeepONets are well equipped to approximate the solution operator of the parametric partial differential equations (PDEs) that govern the behavior of FUS waves with varying initial and boundary conditions (i.e., new transducer locations or spinal cord geometries) without requiring extensive simulations. Trained on simulated pressure maps across diverse patient anatomies, this surrogate model achieves real-time predictions with only a 2% loss on the test set, significantly accelerating the modeling of nonlinear physical systems in heterogeneous domains. By facilitating rapid parameter sweeps in surgical settings, this work provides a crucial step toward precise and individualized solutions in neurosurgical treatments.

超声治疗深度算子网络神经外科实时仿真

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