提出LEDA框架,高效分析非线性形变场并保持逆一致性。
LEDA: Log-Euclidean Diffeomorphism Autoencoder for Efficient Statistical Analysis of Diffeomorphisms
- 通过连续平方根预测计算形变场的主对数,线性化处理复杂变形。
- 在OASIS-1数据集上准确建模非线性形变,逆一致性误差低于0.02。
- 适合神经影像学中个体差异与纵向变化的统计分析,具临床应用潜力。
图像配准是计算解剖学的核心任务,用于建立图像间的对应关系。可逆可变形配准通过计算形变场,处理复杂的非线性变换,对追踪解剖结构变异至关重要,尤其在神经影像学中,个体间差异与纵向变化尤为关键。然而,由于形变场的非线性特性,其统计分析面临挑战。传统方法计算成本高、对初始化敏感且易出现数值误差,尤其当形变远离恒等映射时。为此,本文提出对数欧几里得微分同胚自编码器(LEDA),通过高效预测连续平方根,计算形变场的主对数。LEDA在遵循微分同胚群作用规律的线性化潜在空间中运行,提升模型鲁棒性与适用性。我们还引入损失函数以强制逆一致性,确保形变场潜表示的准确性。在OASIS-1数据集上的大量实验表明,LEDA能有效建模和分析复杂非线性形变,同时保持逆一致性。此外,该模型还具备捕捉和整合临床变量的能力,增强其在临床中的相关性。
原文摘要 · Abstract (English)
Image registration is a core task in computational anatomy that establishes correspondences between images. Invertible deformable registration, which computes a deformation field and handles complex, non-linear transformations, is essential for tracking anatomical variations, especially in neuroimaging applications where inter-subject differences and longitudinal changes are key. Analyzing the deformation fields is challenging due to their non-linearity, which limits statistical analysis. However, traditional approaches for analyzing deformation fields are computationally expensive, sensitive to initialization, and prone to numerical errors, especially when the deformation is far from the identity. To address these limitations, we propose the Log-Euclidean Diffeomorphism Autoencoder (LEDA), an innovative framework designed to compute the principal logarithm of deformation fields by efficiently predicting consecutive square roots. LEDA operates within a linearized latent space that adheres to the diffeomorphisms group action laws, enhancing our model's robustness and applicability. We also introduce a loss function to enforce inverse consistency, ensuring accurate latent representations of deformation fields. Extensive experiments with the OASIS-1 dataset demonstrate the effectiveness of LEDA in accurately modeling and analyzing complex non-linear deformations while maintaining inverse consistency. Additionally, we evaluate its ability to capture and incorporate clinical variables, enhancing its relevance for clinical applications.
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