arXiv:2501.02287eess.IVcs.AI2025-01被引 27

用多模态MRI和新模型精准分割缺血性中风病灶,提升诊断准确率。

Deep Learning-Driven Segmentation of Ischemic Stroke Lesions Using Multi-Channel MRI

  • 融合DWI、ADC和eDWI三模态影像,用DenseNet121+SelfONN架构分割病灶。
  • 在ISLES 2022数据集上,三模态组合达87.49%的Dice系数,优于现有方法。
  • 适合临床影像辅助诊断,尤其对早期微小病灶识别有实用价值。

缺血性中风由脑血管阻塞引起,其病灶具有高度变异性和细微特征,给医学影像分析带来挑战。磁共振成像(MRI)在缺血性中风的诊断与管理中至关重要,但现有分割技术常难以精确勾画病灶。本研究提出一种基于深度学习的多通道MRI病灶分割方法,整合扩散加权成像(DWI)、表观扩散系数(ADC)及增强扩散加权成像(eDWI)。所提架构采用DenseNet121作为编码器,结合自组织操作神经网络(SelfONN)作为解码器,并引入通道与空间复合注意力(CSCA)及双挤压-激励(DSE)模块。同时设计一种融合Dice Loss与Jaccard Loss的加权损失函数以优化性能。在ISLES 2022数据集上训练与评估,仅使用DWI时取得83.88%的骰子相似系数(DSC),加入DWI与ADC后达85.86%,三模态联合使用时达87.49%。该方法显著超越现有技术,有效解决当前分割实践中的关键局限,大幅提高诊断精度与治疗规划能力,为临床决策提供有力支持。

原文摘要 · Abstract (English)

Ischemic stroke, caused by cerebral vessel occlusion, presents substantial challenges in medical imaging due to the variability and subtlety of stroke lesions. Magnetic Resonance Imaging (MRI) plays a crucial role in diagnosing and managing ischemic stroke, yet existing segmentation techniques often fail to accurately delineate lesions. This study introduces a novel deep learning-based method for segmenting ischemic stroke lesions using multi-channel MRI modalities, including Diffusion Weighted Imaging (DWI), Apparent Diffusion Coefficient (ADC), and enhanced Diffusion Weighted Imaging (eDWI). The proposed architecture integrates DenseNet121 as the encoder with Self-Organized Operational Neural Networks (SelfONN) in the decoder, enhanced by Channel and Space Compound Attention (CSCA) and Double Squeeze-and-Excitation (DSE) blocks. Additionally, a custom loss function combining Dice Loss and Jaccard Loss with weighted averages is introduced to improve model performance. Trained and evaluated on the ISLES 2022 dataset, the model achieved Dice Similarity Coefficients (DSC) of 83.88% using DWI alone, 85.86% with DWI and ADC, and 87.49% with the integration of DWI, ADC, and eDWI. This approach not only outperforms existing methods but also addresses key limitations in current segmentation practices. These advancements significantly enhance diagnostic precision and treatment planning for ischemic stroke, providing valuable support for clinical decision-making.

医学图像病灶分割多模态MRI深度学习

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